Sp1/3/4 Cancer Research Results

Sp1/3/4, Specificity Protein: Click to Expand ⟱
Source:
Type:
SP2 (Specificity Protein 2) and SP3 (Specificity Protein 3) are also members of the Sp/KLF (Sp1/Krüppel-like factor) family of transcription factors, similar to SP1. They share some functional similarities but also have distinct roles in cellular processes and cancer biology.
-Sp proteins are a family of transcription factors that play a crucial role in regulating gene expression.
-SP1 is often overexpressed in various types of cancer, including breast, prostate, and lung cancers. However, expression levels of Sp in normal cells and tissues are low to undetectable.

SP inhibitors:
-Curcumin, Resveratrol, EGCG, Genistein, Piperlongumine, Betulinic acid
Scientific Papers found: Click to Expand⟱
2994- EGCG,    Nano-Engineered Epigallocatechin Gallate (EGCG) Delivery Systems: Overcoming Bioavailability Barriers to Unlock Clinical Potential in Cancer Therapy
- Review, Var, NA
BioAv↓, Despite its therapeutic promise, clinical application is constrained by rapid metabolism, poor bioavailability, and inconsistent biodistribution.
NF-kB↓, EGCG modulates oncogenic pathways via NF-κB suppression, caspase activation, and MMP-9 downregulation, demonstrating efficacy across diverse cancer types.
Casp↑,
MMP9↑,
Sp1/3/4↑, marked decrease in Sp1 activity

2986- RES,    Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription
- in-vitro, Cerv, HeLa - in-vitro, AML, HL-60
Sp1/3/4↑, As revealed in Fig. 5A, an increase of Sp1 and a decrease of PU.1 were observed. The Sp1/PU.1 ratio was markedly induced 24 h after the addition of Rsv to the culture medium

2987- RES,    Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1
- in-vivo, Nor, NA
*VEGF↑, effect of resveratrol on significant upregulation of the protein expression profiles of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptor Flk-1, 3 wk after MI.
*iNOS↑, Pretreatment with resveratrol also increased nitric-oxide synthase (inducible NOS and endothelial NOS) along with increased antiapoptotic and proangiogenic factors nuclear factor (NF)-kappaB and specificity protein (SP)-1.
*NF-kB↑,
*Sp1/3/4↑,
*cardioP↑, demonstrate increased capillary density as well as improved left ventricular function by pharmacological preconditioning with resveratrol 3 wk after MI

942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Cav1↑, may impair the glycolytic metabolism of breast cancer cells by activating Caveolin-1 (Cav-1)
Glycolysis↓, Ursolic Acid Impairs the Glycolytic Metabolism
cMyc↓, ursolic acid (1~30 μM) treatment significantly attenuated the protein expression levels of both the glycolysis-related proteins (c-Myc and LDH-A)
LDHA↓,
Nrf1↓, and the mitochondrial respiration-related proteins (Nrf1 and PGC-1α)
PGC-1α↓,
Sp1/3/4↑, Mechanistically, ursolic acid could activate SP1-mediated CAV1 transcription by promoting SP1 expression
TumCG↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Nrf1↓, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↓, 1,  

Core Metabolism/Glycolysis ⓘ

Cav1↑, 1,   cMyc↓, 1,   Glycolysis↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

Casp↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

MMP9↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

iNOS↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Sp1/3/4, Specificity Protein
2 Resveratrol
1 EGCG (Epigallocatechin Gallate)
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:506  State#:%  Dir#:2
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