miR-205 Cancer Research Results

miR-205, microRNA 205: Click to Expand ⟱
Source:
Type: microRNA
miR-205 was found to be either up- or downregulated in several cancers according to the subtype, cell of origin or stage of tumor progression.
Scientific Papers found: Click to Expand⟱
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓,
AR↓, Treatment with PLGA-CUR NPs drastically decreases the AR expression level (Figure 5C) compared to free curcumin.
STAT3↓, PLGA-CUR treatment inhibited the expression of STAT3 and phosphorylation of AKT at even the lowest concentration
p‑Akt↓,
Mcl-1↓,
Bcl-xL↓,
cl‑PARP↑, Prostate cancer cells treated with CUR or PLGA-CUR NPs exhibited PARP cleavage and inhibited the expression of anti-apoptotic proteins, Bcl-XL and Mcl-1
miR-21↓, 9-fold reduction in expression of the oncomir, miR-21, in prostate cancer cells (C4-2 and DU-145) t
miR-205↑,
TumCG↓, PLGA-CUR NPs were capable of reducing both in vitro and in vivo prostate cancer cell growth,
TumCP↓, data suggest that curcumin can effectively suppress prostate cancer cell proliferation, invasion, angiogenesis, and metastasis
TumCI↓,
angioG↓,
TumMeta↓,

818- GAR,  GB,    Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
- in-vitro, Lung, A549
miR-205↑,
Let-7↑,
Apoptosis↑, Garcinol Potentiates Apoptosis Induction by Erlotinib
miR-200b↑,
miR-218↑,

4699- PTS,    Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vivo, BC, MDA-MB-231
TumCMig↓, Pterostilbene inhibited the migratory and invasive potential of triple-negative MDA-MB-231 and Hs578t cells,
TumCI↓,
E-cadherin↑, accompanied by the up-regulation of E-cadherin and down-regulation of Snail, Slug, vimentin and ZEB1.
Snail↓,
Slug↓,
Vim↓,
Zeb1↑,
miR-205↑, significant up-regulation of miR-205, which resulted in the reduction of Src expression in pterostilbene-treated breast cancer cells
Src↓,
TumCG↓, suppressed tumor growth and metastasis in MDA-MB-231-bearing NOD/SCID mice
FAK↓, by reducing Src/Fak signaling
EMT↓, Our findings provide supports for the usage of pterostilbene as an inhibitor of EMT process and potential candidate for adjuvant therapy.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Bcl-xL↓, 1,   Mcl-1↓, 1,  

Transcription & Epigenetics ⓘ

miR-205↑, 3,   miR-21↓, 1,   miR-218↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Let-7↑, 1,   Src↓, 1,   STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   FAK↓, 1,   miR-200b↑, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-205, microRNA 205
1 Curcumin
1 Garcinol
1 gefitinib, erlotinib
1 Pterostilbene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:511  State#:%  Dir#:2
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