ERβ/ESR2 Cancer Research Results

ERβ/ESR2, Estrogen receptor beta also known as NR3A2: Click to Expand ⟱
Source:
Type:
ERβ (or NR3A2) one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ is encoded by the ESR2 gene.
ERβ is a potent tumor suppressor and plays a crucial role in many cancer types such as prostate cancer and ovarian cancer.
Expression levels of the full length ERβ1 isoform are often lower in aggressive cancers as compared to normal tissue. High ERβ1 expression is associated with improved overall survival in women with breast cancer. The promise of ERβ activation, as a potential targeted therapy, is based on concurrent activation of multiple tumor suppressor pathways with few side effects compared to chemotherapy.
Scientific Papers found: Click to Expand⟱
983- Api,    Apigenin acts as a partial agonist action at estrogen receptors in vivo
- in-vivo, NA, NA
ERα/ESR1↑,
ERβ/ESR2↑,

7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, Isoliquiritigenin (ISL), a flavonoid phytoestrogen, has shown anti-tumour activities against various cancers.
tumCV↓, The experimental results show that ISL reduced the viability of SW480 and HCT116 cells, induced apoptosis, blocked the cell cycle in the G2 phase in vitro, and suppressed xenograft tumour growth in vivo.
Apoptosis↑, This study indicates that ISL can inhibit the growth of CRC cells and induce apoptosis
TumCCA↑,
TumCG↓,
PI3K↓, ISL significantly down-regulated the protein expression of PIK3CG, AKT, p-AKT, p-GSK3β, CDK1, NF-κB and Bcl-2; up-regulated ESR2 and Bax;
Akt↓,
p‑Akt↓,
p‑GSK‐3β↓,
CDK1↓,
NF-kB↓,
Bcl-2↓,
ERβ/ESR2↑,
BAX↑,
Bax:Bcl2↑, decreased the ratio of p-AKT/AKT and p-GSK3β/GSK3β; and increased the Bax/Bcl-2 ratio
ROS↑, ISL Induces ROS Accumulation in CRC Cells

7827- KaempF,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, Kaempferol (3,4′,5,7-tetrahydroxyflavone) showed neuroprotective activity in various AD models.
*Learn↑, improved the spatial learning and memory impairment in SZT-injected (i.c.v.) rats
*memory↑,
*antiOx↑, by the mechanisms of antioxidation and antineuroinflammation
*Inflam↓,
*Aβ↓, Aβ-induced damages was also ameliorated by kaempferol as evidenced by the improved cognitive and memory function in Aβ1−40 -injected (i.c.v.) mice
*cognitive↑,
*BDNF↑, Mechanisms for those effects involved the activation of the cytoprotective BDNF/TrkB/ CREB pathway, enhancement of the antiapoptotic Erβ/ERK1/ 2 pathway, and inhibition of oxidative stress.
*TrkB↑,
*CREB↑,
*ERβ/ESR2↑,
*ERK↑,
*ROS↓,
*AChE↓, inhibited AChE activity
*Dose↑, kaempferol-3-Orutinoside, isoquercitrin, isorhamnetin, and rutin increased to 24.25, 18.67, 26.06, and 11.67 mg/100 g dry weight in mung bean sprouts (at the fifth day of sprouting),

156- Ralox,  Tam,  GEN,  CUR,    Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ERβ/ESR2↑,
TumCG↓, Regulation of PC cell growth by raloxifen, tamoxifen, genistein and curcumin
TumCMig↓, genistein and curcumin reduced the migratory activity of DU145 cells by 43% and 25%, respectively; for PC3 cells the reduction was about 40%
FAK↓, genistein seemed to be an inhibition of the activation of Focal Adhesion Kinase (FAK) and mitogen-activated kinase (MAPK) p38-heat shock protein 27 that mediates detachment and cellular migration respectively
p38↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,   PI3K↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

FAK↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↑, 1,   ERβ/ESR2↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ERα/ESR1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: ERβ/ESR2, Estrogen receptor beta also known as NR3A2
1 Apigenin (mainly Parsley)
1 Isoliquiritigenin
1 Kaempferol
1 Mung Bean Sprouts
1 raloxifen
1 tamoxifen
1 Genistein (soy isoflavone)
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:515  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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