MPT Cancer Research Results

MPT, mitochondrial permeability transition: Click to Expand ⟱
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MPT refers to an alteration in the permeability of the inner mitochondrial membrane (IMM), Mitochondrial permeability transition (MPT) refers to a process involving the opening of the mitochondrial permeability transition pore (mPTP), which can lead to the loss of mitochondrial membrane potential, disruption of ATP synthesis, and release of pro-apoptotic factors into the cytosol. This process is critical in various physiological and pathological contexts, including cancer.

Mitochondrial permeability transition plays a significant role in cancer biology, with its dysregulation often associated with poor prognosis and protumorigenic effects. The specific roles of MPT can vary by cancer type and context.
Scientific Papers found: Click to Expand⟱
5266- 3BP,    3-bromopyruvate-based agent KAT-101
- Review, Var, NA
eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,
5978- AgNPs,    Biological synthesis of silver nanoparticles and their medical applications
- Review, Var, NA
Wound Healing↑, AntiCan↑, other↑, MPT↑, ROS↑, other↑, DNAdam↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
6396- ANE,  FEO,    Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
- in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27↑, NF-kB↓, eff↑,
6398- ANE,    trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells
- in-vitro, OS, MG63
*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,
6544- BSB,    Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis
- in-vitro, GBM, NA
*Inflam↓, *AntiBio↑, selectivity↑, Apoptosis↑, Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, MPT↑, ROS↑, eff↓, OCR↓, eff↑,
6545- BSB,    The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes
MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,
6558- BSB,    Involvement of mitochondrial permeability transition pore opening in α-bisabolol induced apoptosis
OCR↓, MPT↑, selectivity↑, ROS↑, eff↓, *ROS∅, cl‑PARP↑, MMP↓, eff↑,
5835- CAP,    Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+-mediated mitochondrial pathway
- in-vitro, GBM, U251
tumCV↓, Apoptosis↑, selectivity↑, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Casp↑, eff↑, MPT↑, ETC↓, Casp3↑, Casp9↑,
5826- CAP,    Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload
- in-vitro, Thyroid, NA
TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, eff↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
6134- CHr,  QC,  RT,    Comparative Pharmacokinetics and Safety of a Micellar Chrysin–Quercetin–Rutin Formulation: A Randomized Crossover Trial
- Trial, Nor, NA
Dose↝, BioAv↑, MPT↑, eff↑, Half-Life↑,
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
141- CUR,    Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer
- in-vivo, Pca, PC3
BAX↑, Bcl-2↓, TumCG↓, TumVol↓, TumW↓, Apoptosis↑, AR↓, Ca+2↑, MPT↑,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
PDK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
6697- DFC,    Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS
Inflam↓, Casp3↑, Casp8↑, Casp9↑, MPT↑, mt-ROS↑,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, eff↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,

Showing Research Papers: 1 to 27 of 27

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSH/GSSG↓, 2,   GSTZ1↝, 1,   H2O2↑, 2,   mt-H2O2↑, 1,   lipid-P↑, 3,   NADH↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   ROS↑, 18,   ROS⇅, 1,   mt-ROS↑, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 3,   ETC↓, 3,   mitResp↓, 1,   mitResp↑, 1,   MMP?, 1,   MMP↓, 14,   MPT↑, 27,   mtDam↑, 5,   OCR↓, 3,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↑, 1,   cMyc↓, 1,   FASN↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   lactateProd↑, 1,   LDH↓, 1,   PDH↓, 1,   PDK1↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   TCA?, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↑, 15,   Bak↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 1,   Casp↑, 8,   Casp3↑, 12,   Casp6↑, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 7,   Cupro↑, 1,   Cyt‑c↑, 13,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   p27↑, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,   TRPV1↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other↑, 2,   other↝, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 4,   EMT↓, 3,   p‑ERK↓, 1,   FOXO3↓, 1,   mTOR↓, 1,   mTORC2↓, 1,   PI3K↓, 4,   STAT3↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 4,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Ca+2↑, 5,   E-cadherin↑, 2,   FAK↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   Snail↓, 2,   TIMP1↑, 1,   TRIB3↑, 1,   TumCI↓, 3,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 3,   TumCP↑, 1,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   EPR↑, 1,   Hif1a↓, 2,   NO↓, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   CRP↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 3,   p‑NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   ChemoSen↑, 4,   DDS↑, 2,   Dose↝, 5,   eff↓, 4,   eff↑, 12,   eff↝, 2,   Half-Life↑, 2,   RadioS↑, 3,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   IL6↓, 1,   LDH↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 3,   NP/CIPN↑, 1,   Obesity↓, 1,   OS↑, 1,   Remission↑, 1,   Risk↓, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Wound Healing↑, 1,  
Total Targets: 171

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   ROS↓, 2,   ROS↑, 1,   ROS∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP∅, 1,   MPT↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2∅, 1,   Cyt‑c↑, 1,   TRPV1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   eff↓, 1,   Half-Life↓, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   neuroP↑, 1,   toxicity∅, 1,  
Total Targets: 29

Scientific Paper Hit Count for: MPT, mitochondrial permeability transition
3 α-Bisabolol / Chamomile oil
3 Capsaicin
3 Magnetic Fields
2 Anethole/trans-Anethole
2 Chrysin
2 Curcumin
2 Magnetic Field Rotating
1 3-bromopyruvate
1 Silver-NanoParticles
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Celecoxib
1 chitosan
1 Quercetin
1 Rutin
1 Copper and Cu NanoParticles
1 methylseleninic acid
1 Dichloroacetate
1 Diclofenac
1 Eugenol
1 HydroxyTyrosol
1 Bicarbonate(Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:519  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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