lysoMP Cancer Research Results

lysoMP, lysosomal membrane permeabilization: Click to Expand ⟱
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Different forms of stress can induce lysosomal membrane permeabilization (LMP), resulting in the translocation to the cytoplasm of intralysosomal components, such as cathepsins, inducing lysosomal-dependent cell death (LDCD).
Lysosomes are single-membrane cell organelles, the main cellular function of which is to degrade extracellular material internalized by endocytosis/phagocytosis. It is now clear that lysosomes are more than a cellular “suicide bag.” Multiple pathways converge in this organelle, including endocytosis/phagocytosis, autophagy and exocytosis, and lysosomes are key players in several types of cell death. The best-studied mechanism by which LDCD is induced is ROS-mediated lysosomal destabilization.
Lysosomal membrane permeabilization (LMP) refers to the disruption of the lysosomal membrane, leading to the release of lysosomal contents, including hydrolytic enzymes, into the cytoplasm. This process can have significant implications for cellular homeostasis, apoptosis, and cancer biology.

Lysosomal membrane permeabilization is a critical event in cancer biology, often associated with tumor progression and poor prognosis. Increased LMP can promote protumorigenic processes, while maintaining lysosomal integrity may have protective effects against cancer development.


Scientific Papers found: Click to Expand⟱
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, We found that DTS inhibits proliferation and migration of CRL-2335 cells derived from a patient of West African ancestry.
TumCMig↓,
Bak↑, DTS induces the expression of pro-apoptotic genes BAK1, GADD45a, and LTA in CRL2335 cells though it primarily promotes caspase-independent CRL-2335 cell death.
GADD45A↑,
LTA/TNF-β↑, Finally, Kaplan-Meier survival curves reveal that higher expression of BAK1 and LTA in tumors from patients with TNBC is associated with longer relapse-free survival.
lysoMP↑, DTS promotes lysosomal membrane permeabilization and cathepsin B release in CRL2335 cells
P450↓, We previously found that DTS suppressed cytochrome P450 1 (CYP1) activity and binds to the CYP1A1 active site
cl‑PARP↑, DTS induces PARP in a dose-dependent manner (Figure 7) and cleaved PARP is expressed more robustly than cleaved caspase 3.
Dose↝, it is recommended that patients use P. alliacea twice daily for an extended period [67], to allow sufficient levels to accumulate in the plasma.

189- MFrot,  MF,    Cancer treatment by magneto-mechanical effect of particles, a review
- Review, Var, NA
CellMemb↑, damage the cell membrane
lysoMP↑, through heat and/or mechanical damage
ERK↑,
Apoptosis↑,

215- MFrot,  MF,    Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
- in-vitro, PC, CAF
TumVol↓, 34% ratio in cell death induction
lysoMP↑, induce lysosome membrane permeabilization RMF exposure caused lysosome rupture
CAFs/TAFs↓,
eff↑, disrupt the tumor microenvironment through mechanical forces generated by mechanical activation of magnetic nanoparticles upon low-frequency rotating magnetic field exposure

5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, SLM induces a potent endoplasmic reticulum (ER) stress followed by the trigger of the unfolded protein response (UPR) and an aberrant autophagic flux that culminated in necrosis due to mitochondria and lysosomal alterations.
UPR↑,
autoF↓, SLM treatment does not trigger apoptosis and blocks the autophagy flux in glioma cell line
lysosome↝,
ROS↑, aberrant autophagic flux was orchestrated by the production of Reactive Oxygen Species (ROS)
lipid-P↑, our data suggest that in our system the oxidative stress blocks the autophagic flux through lipid oxidation.
CSCs↓, SLM induces a potent antitumor effect in brain tumor stem cells (BTSCs) and established adult and pediatric glioma cell lines in vitro
necrosis↑, SLM induces necrosis cell death
ATP↓, with increasing doses of SLM displayed a decrease in intracellular ATP levels
MMP↓, SLM treated cells displayed significantly lower ΔΨm than untreated cells
MOMP↑, SLM induces mitochondrial MOMP.
DNAdam↑, We observed double strand breaks in SLM-treated cells (Figure 4C) and it is possible that this DNA damage is induced as a consequence of AIF internalization.
AIF↑,
lysoMP↑, hypothesis that SLM treatment triggers an autophagic process that cannot proceed adequately because of LMP resulting from oxidative stress.
MitoP↑, In addition, impairment of mitochondrial activity would trigger mitophagy, with engulfment of the organelle and initiation of autophagy.
Ca+2↑, The elevated levels of calcium and ROS inside mitochondria results in MOMP


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bak↑, 1,   lysoMP↑, 4,   MOMP↑, 1,   necrosis↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autoF↓, 1,   lysosome↝, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   GADD45A↑, 1,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   ERK↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CAFs/TAFs↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

LTA/TNF-β↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   P450↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: lysoMP, lysosomal membrane permeabilization
2 Magnetic Field Rotating
2 Magnetic Fields
1 DTS(dibenzyl trisulphide) from Anamu
1 salinomycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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