CEBPA Cancer Research Results

CEBPA, CCAAT/enhancer binding protein (C/EBP), alpha: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
CEBPA (CCAAT/enhancer-binding protein alpha) is a transcription factor that plays a significant role in regulating gene expression related to cell differentiation, proliferation, and metabolism. It is particularly important in the context of hematopoiesis (the formation of blood cells) and has been implicated in various cancers, especially acute myeloid leukemia (AML).
In general, altered expression of CEBPA, particularly downregulation, is often associated with more aggressive tumor behavior and poorer prognosis in various cancer types.


Scientific Papers found: Click to Expand⟱
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, psPEF displayed strong growth inhibitory effects on HeLa cells.
Apoptosis↑, psPEF led to marked cell apoptosis and cell cycle arrest at the G2/M phase.
TumCCA↑,
GRP78/BiP↑, psPEF affected the phosphorylation levels of endoplasmic reticulum sensors and upregulated the expression of glucose-regulated protein 78 (GRP78), glucose-regulated protein 94 (GRP94) and CCAAT enhancer-binding protein (C/EBP) homologous protein (CH
GRP94↑,
CEBPA↑,
CHOP↑,
Ca+2↑, These changes were accompanied by the elevation of intracellular Ca2+ concentrations
Casp12↑, activation of caspase-12, -9 and -3, led to the release of cytochrome c, as well as the upregulation of Bax and the downregulation of Bcl-2, as observed in the HeLa cells.
Casp9↑,
Casp3↑,
Cyt‑c↑,
BAX↑,
Bcl-2↓,
ER Stress↑, at least partially, via the endoplasmic reticulum stress and caspase-dependent signaling pathways.
MMP↓, which subsequently leads to mitochon- drial depolarization and initiates a cell death cascade


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp12↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CEBPA↑, 1,  

Migration ⓘ

Ca+2↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CEBPA, CCAAT/enhancer binding protein (C/EBP), alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:54  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page