NO Cancer Research Results

NO, Nitric Oxide: Click to Expand ⟱
Source:
Type:
Once the cancer has begun, NO seems to play a protumoral role rather than antitumoral one as the concentration required to cause tumor cell cytotoxicity cannot be achieved by cancer cells.
The mechanistic roles of nitric oxide (NO) during cancer progression have been important considerations since its discovery as an endogenously generated free radical. Nonetheless, the impacts of this signaling molecule can be seemingly contradictory, being both pro-and antitumorigenic, which complicates the development of cancer treatments based on the modulation of NO fluxes in tumors. At a fundamental level, low levels of NO drive oncogenic pathways, immunosuppression, metastasis, and angiogenesis, while higher levels lead to apoptosis and reduced hypoxia and also sensitize tumors to conventional therapies. However, clinical outcome depends on the type and stage of the tumor as well as the tumor microenvironment.
Nitric oxide is generated by three main nitric oxide synthase isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS).

– In many cancers, especially under inflammatory conditions, iNOS expression is upregulated. In contrast, eNOS levels may also be altered in cancers such as breast or prostate cancer.

• Expression Patterns in Tumors:
– Elevated iNOS expression is commonly observed in various tumor types (e.g., colon, breast, lung, and melanoma) and is often associated with an inflammatory microenvironment.

– Changes in eNOS and nNOS expression have also been reported and may contribute to angiogenesis and tumor blood flow regulation.
Scientific Papers found: Click to Expand⟱
4382- AgNPs,    Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
- in-vitro, Nor, RAW264.7
*GSH↓, *NO↑, *TNF-α↑, *MMP3↑, *MMP11↑,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
4558- AgNPs,    Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells
- in-vitro, PC, PANC1
ROS↑, selectivity↑, NO↑, SOD↓, GPx4↓, Catalase↓, TumCCA↑, MMP↓,
398- AgNPs,    Silver nanoparticles induced testicular damage targeting NQO1 and APE1 dysregulation, apoptosis via Bax/Bcl-2 pathway, fibrosis via TGF-β/α-SMA upregulation in rats
- in-vivo, Testi, NA
Bcl-2↓, Casp3↑, GSH↓, MDA↑, NO↑, H2O2↑, SOD↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
1603- Cu,  BP,  SDT,    Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response
- in-vitro, BC, 4T1 - in-vivo, NA, NA
GSH↓, Fenton↑, ROS↑, NO↑, sonoS↑, eff↑, NO↑, *toxicity∅, eff?,
6050- CUR,  SeNPs,    Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *Aβ↓, *P53↓, *tau↓, *NRF2↓, *TNF-α↓, *NO↑, *Catalase↑, *antiOx↑, *Inflam↓,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, NA, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
4343- H2,    Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation
- vitro+vivo, NA, NA
*antiOx↑, *AntiAg↑, *NO↑, *ERK↑,
2238- MF,    Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
- Review, Var, NA
*BMD↑, *VGCC↑, *Ca+2↑, *NO↑, *eff↓,
4105- MF,    Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases
- Review, AD, NA
*Inflam↓, *neuroP↑, *NO↑, *ROS↓, *NO↓, *MCP1↑, *HSP70/HSPA5↑, *antiOx↑, *NRF2↑, *NF-kB↓,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
4101- MF,    Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation
- Human, Stroke, NA
*motorD↑, *cognitive↑, *eff↑, *NO↑, *other↝, *neuroP↑,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, NA, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
229- MFrot,  MF,    Molecular mechanism of effect of rotating constant magnetic field on organisms
- in-vivo, Nor, NA
*NO↑, *5HT↓, *eff↝, *eff↝, *β-Endo↑, *other↓,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
4954- PEITC,    Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
- vitro+vivo, Ovarian, SKOV3
ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,
4944- PEITC,    Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations
- in-vitro, Oral, NA
TumCG↓, TumCCA↑, Apoptosis↑, ROS↑, NO↑, GSH↓, MMP↓, DNAdam↑, ATM↑, Chk2↑, P53↑, eff↓,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
2941- PL,    Selective killing of cancer cells by a small molecule targeting the stress response to ROS
- in-vivo, BC, MDA-MB-231 - in-vitro, OS, U2OS - in-vitro, BC, MDA-MB-453
ROS↑, Apoptosis↑, selectivity↑, *ROS∅, GSH↓, GSSG↑, H2O2↑, NO↑, Half-Life?,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1937- TQ,    Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models
- NA, Nor, 3T3
*ROS↓, *antiOx↓, *BioAv↓, *BioAv↑, *NO↑, *SOD↑, *GPx↑, *Catalase↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,

Showing Research Papers: 1 to 31 of 31

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 31

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   Fenton↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 1,   GSSG↑, 1,   GSTs↑, 1,   H2O2↑, 4,   HO-1↑, 2,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↑, 2,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 18,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 3,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 3,   CDC25↓, 1,   MMP↓, 7,   mtDam↑, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 4,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 1,   HK2↓, 4,   lactateProd↓, 4,   LAR↓, 1,   LDHA↓, 1,   PKM2↓, 3,  

Cell Death ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 8,   BAX↑, 1,   Bcl-2↓, 5,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 2,   Casp↑, 2,   Casp3↑, 5,   Casp8↑, 2,   Casp9↑, 2,   Chk2↑, 1,   Cyt‑c↑, 4,   Diablo↑, 3,   DR4↑, 2,   DR5↑, 2,   FADD↑, 1,   hTERT/TERT↓, 1,   ICAD↓, 2,   JNK↑, 2,   MAPK↑, 1,   MCT1↓, 1,   Necroptosis↑, 1,   p27↑, 3,   p38↑, 1,   survivin↓, 2,   TNFR 1↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   EZH2↓, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   sonoS↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 2,   DNAdam↑, 6,   DNMT1↓, 2,   p16↑, 1,   P53↑, 3,   cl‑PARP↑, 4,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

p‑CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CSCs↓, 3,   EMT↓, 2,   ERK↓, 1,   p‑ERK↓, 2,   FOXM1↓, 1,   FOXO↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   IGFR↓, 1,   mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PTEN↑, 1,   SOX2↓, 1,   STAT1↓, 1,   STAT3↓, 5,   TOP2↓, 1,   TumCG↓, 2,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 4,   cal2↓, 1,   CD31↓, 1,   CXCL12↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   LAMs↓, 1,   miR-22↑, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   TGF-β↓, 1,   TumCP↓, 5,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 3,   LOX1↓, 1,   NO↑, 20,   PDGFR-BB↑, 1,   VEGF↓, 4,   VEGFR2↓, 1,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   COX2↑, 1,   HCAR1↓, 1,   Igs↑, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 5,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 6,   Dose?, 1,   Dose↝, 2,   eff?, 1,   eff↓, 5,   eff↑, 7,   Half-Life?, 1,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 3,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,   OS↑, 1,   TumVol↓, 1,   Weight↑, 1,  
Total Targets: 203

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 5,   Catalase↑, 6,   GPx↑, 2,   GPx3↑, 1,   GSH↓, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 5,   ROS↑, 1,   ROS∅, 1,   SOD↑, 5,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   p‑cMyc↑, 1,  

Cell Death ⓘ

iNOS↓, 1,   p‑JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 2,   VGCC↑, 1,   Wnt↑, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↑, 3,   Cartilage↑, 1,   FAK↑, 1,   MMP11↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 1,   TGF-β↑, 1,   β-catenin/ZEB1↑, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 2,   NO↑, 12,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   IL1β↓, 1,   IL6↓, 1,   IL6↑, 1,   Inflam↓, 6,   MCP1↑, 1,   NF-kB↓, 1,   PGE2↓, 1,   PGE2↑, 2,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,   AChE↓, 1,   BDNF↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   eff↝, 2,  

Clinical Biomarkers ⓘ

BMD↑, 1,   IL6↓, 1,   IL6↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 3,   memory↑, 1,   motorD↑, 1,   neuroP↑, 3,   Pain↓, 1,   QoL↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 87

Scientific Paper Hit Count for: NO, Nitric Oxide
6 Magnetic Fields
4 Silver-NanoParticles
3 Curcumin
2 Boswellia (frankincense)
2 Fisetin
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Thymoquinone
2 Ursolic acid
1 Copper and Cu NanoParticles
1 Black phosphorus
1 SonoDynamic Therapy UltraSound
1 Selenium NanoParticles
1 EGCG (Epigallocatechin Gallate)
1 Shilajit/Fulvic Acid
1 Hydrogen Gas
1 Magnetic Field Rotating
1 Propolis -bee glue
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:563  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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