lysosome Cancer Research Results

lysosome, lysosome/lysosomal: Click to Expand ⟱
Source:
Type:
Lysosomes are membrane-bound organelles that play a crucial role in cellular homeostasis by degrading and recycling various biomolecules, including proteins, lipids, and carbohydrates. They contain a variety of hydrolytic enzymes that facilitate these processes. In the context of cancer, lysosomes are increasingly recognized for their roles in tumor biology, influencing cell survival, proliferation, and metastasis.

Lysosomes are generally considered protumorigenic in many contexts. Their role in degrading extracellular matrix components and releasing proteolytic enzymes can facilitate tumor cell invasion and metastasis. Additionally, lysosomes can support cancer cell survival by providing nutrients through autophagy and recycling processes.
Scientific Papers found: Click to Expand⟱
4868- Uro,    Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, Long-term UA treatment significantly improved learning, memory and olfactory function in different AD transgenic mice.
*Aβ↓, UA also reduced Aβ and Tau pathologies, and improved long-term potentiation
*tau↓,
*MitoP↑, UA activated autophagy/mitophagy via increasing lysosomal functions
*lysosome↑,
*CTSZ↝, UA improved lysosomal function and normalized lysosomal cathepsins, especially targeting cathepsin Z, to restore lysosomal function in AD


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Autophagy & Lysosomes ⓘ

lysosome↑, 1,   MitoP↑, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↝, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: lysosome, lysosome/lysosomal
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:616  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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