IRE1 Cancer Research Results

IRE1, Inositol-Requiring Enzyme 1: Click to Expand ⟱
Source:
Type:
A protein that plays a crucial role in the unfolded protein response (UPR), a cellular stress response mechanism that helps maintain endoplasmic reticulum (ER) homeostasis.
IRE1 is activated in response to ER stress, which occurs when the ER is overwhelmed with misfolded or unfolded proteins.
IRE1 is overexpressed in various types of cancer, including breast, lung, colon, and pancreatic cancer. This overexpression is often associated with poor prognosis and reduced overall survival.
Scientific Papers found: Click to Expand⟱
5145- AgNPs,    Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D
Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,
319- AgNPs,    Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis
Apoptosis↑, Ca+2↑, ER Stress↑, PERK↑, IRE1↑, cl‑ATF6↑,
354- AgNPs,    Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function
- in-vitro, neuroblastoma, SH-SY5Y
TumCD↑, ER Stress↑, GRP78/BiP↑, p‑PERK↑, CHOP↑, Ca+2↑, XBP-1↑, p‑IRE1↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5674- BTZ,    Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic, anti-tumor effects
- in-vivo, GBM, NA - in-vivo, HNSCC, NA
ER Stress↑, GRP78/BiP↑, CHOP↑, PERK↑, IRE1↑, UPR↑, HSP70/HSPA5↑, HSP90↑, eff↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
677- EGCG,    IRE1_a">Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2 α /ATF4 and IRE1 α
- in-vitro, CRC, HT-29
ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
3362- QC,    The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action
- in-vitro, Cerv, HeLa
Apoptosis↑, cycD1/CCND1↓, Casp3↑, GRP78/BiP↑, CHOP↑, tumCV↓, IRE1↑, p‑PERK↑, c-ATF6↑, ER Stress↑,
3065- RES,    Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
- in-vitro, lymphoma, NA
UPR↑, IRE1↑, p‑eIF2α↑, PERK↑, ATF6↑, GRP78/BiP↑, GRP94↑, CHOP↑, GADD34↑, ATF4↑, XBP-1↑, Ca+2↑, ER Stress↑,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
3416- TQ,    Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 253J - in-vitro, Nor, SV-HUC-1
TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   Copper↑, 1,   GPx4↓, 2,   GSH↓, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↓, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 6,   mt-ROS↑, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   EGF↓, 1,   MMP↓, 5,   mtDam↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   Glycolysis↓, 2,   LDH↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 3,   Apoptosis↑, 8,   Bak↑, 1,   BAX↑, 3,   Bcl-2↓, 4,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp7↑, 2,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 7,   Diablo↑, 2,   DR5↑, 2,   GADD34↑, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 2,   NOXA↑, 1,   p27↑, 3,   survivin↓, 1,   TumCD↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 3,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 3,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   CHOP↓, 1,   CHOP↑, 10,   eIF2α↑, 3,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↑, 15,   GRP78/BiP↓, 1,   GRP78/BiP↑, 11,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,   IRE1↑, 16,   p‑IRE1↑, 1,   PERK↑, 9,   p‑PERK↑, 2,   UPR↑, 4,   XBP-1↑, 3,  

Autophagy & Lysosomes ⓘ

LC3A↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53↑, 4,   PARP↝, 1,   cl‑PARP↑, 4,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   Cyc↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 3,   P21↑, 4,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 3,   EMT↓, 3,   ERK↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   mTORC1↓, 2,   mTORC2↓, 1,   PI3K↓, 2,   PTEN↑, 1,   TCF-4↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 2,   Wnt↓, 3,  

Migration ⓘ

AP-1↓, 2,   Ca+2↑, 6,   CAFs/TAFs↓, 1,   E-cadherin↑, 3,   MMP2↓, 3,   MMP7↓, 2,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 2,   ROCK1↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCA↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 2,   Twist↓, 2,   uPA↓, 3,   Vim↓, 4,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 9,   EGFR↓, 1,   Hif1a↓, 1,   NO↑, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IKKα↑, 1,   NF-kB↓, 3,   PD-L1↓, 1,   PGE2↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose↝, 1,   eff↓, 1,   eff↑, 10,   eff↝, 2,   Half-Life↝, 1,   RadioS↑, 3,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 1,   LDH↑, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   Risk↓, 1,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 159

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GSH↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   p‑cMyc↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,   ERK↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam?, 1,   Inflam↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 14

Scientific Paper Hit Count for: IRE1, Inositol-Requiring Enzyme 1
3 Silver-NanoParticles
3 Fisetin
2 EGCG (Epigallocatechin Gallate)
1 Baicalein
1 Bortezomib
1 Carvacrol
1 Fenbendazole
1 Quercetin
1 Resveratrol
1 Shikonin
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:618  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page