GlucoseCon Cancer Research Results

GlucoseCon, Glucose Consumption: Click to Expand ⟱
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Glucose consumption is often elevated in cancer cells due to an increased reliance on glycolysis for energy production, even in the presence of oxygen. This phenomenon, known as the Warburg effect, is a metabolic shift that allows cancer cells to rapidly proliferate and survive in nutrient-poor environments.

The increased glucose consumption in cancer cells can be detected using positron emission tomography (PET) scans, which measure the uptake of a glucose analog labeled with a radioactive tracer.
Scientific Papers found: Click to Expand⟱
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, NA, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3441- ALA,    α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
- in-vivo, AD, NA
*tau↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, *VEGF↑, *HO-1↑, *Glycolysis↑, *HK1↑, *PGC-1α↑, *Hif1a↑, *neuroP↑,
3447- ALA,    Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells
- in-vitro, AD, SH-SY5Y
*ATP↑, *MMP↑, *ROS↓, *GlucoseCon↑, *GSH↑, *neuroP↑, *cognitive↑, *Ach↑, *Inflam↓, *Aβ↓, OXPHOS↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3543- ALA,    The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
- Study, AD, NA
*cognitive↑, *antiOx↑, *Inflam↓, *neuroP↑, *Ach↑, *ROS↓, *GlucoseCon↑, *lipid-P↓, *GSH↑, *Acetyl-CoA↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
1226- OLST,    Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation
- vitro+vivo, GC, NA
PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,
3910- PS,    Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model
- in-vivo, AD, NA
*memory↑, *neuroP↑, *GlucoseCon↑, *ChAT↑,
3022- RosA,    Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
- in-vitro, Sepsis, NA
*cognitive↑, *neuroP↑, *GlucoseCon↑, *Hif1a↓,
4312- VitB1/Thiamine,    Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
- Review, AD, NA
*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4315- VitB2,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
*GlucoseCon↑, *ATP↑, *homoC↓, *ROS↓, *Aβ↓, *Aβ↓, *Inflam↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 1 to 25 of 25

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 25

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↑, 1,   ROS↑, 5,   ROS⇅, 1,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   Insulin↓, 2,   OCR↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↑, 4,   cMyc↓, 1,   FASN↓, 1,   FDG↓, 1,   GlucoseCon↑, 5,   Glycolysis↓, 2,   Glycolysis↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 2,   lactateProd↑, 2,   LDHA↑, 1,   lipidLev↑, 1,   NADPH↓, 1,   PDH↓, 1,   PDH↑, 1,   PFK1↓, 1,   PGM1∅, 1,   polyA↓, 1,   Pyruv↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↑, 2,   Bak↑, 1,   Casp9↑, 1,   p27↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   mTOR↓, 1,   mTORC1↓, 1,   PI3K↑, 2,   p‑STAT3↓, 1,   p‑STAT5↓, 1,   TumCG↓, 4,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   EGR4↓, 1,   Hif1a↑, 2,  

Barriers & Transport ⓘ

GLUT1↑, 2,   GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 1,   eff↓, 5,   eff↑, 5,   Half-Life↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   neuroP↑, 1,  
Total Targets: 77

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 10,   mt-antiOx↑, 1,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 11,   GSR↑, 1,   GSTs↑, 1,   H2O2∅, 1,   HK1↑, 1,   HO-1↑, 4,   lipid-P↓, 5,   MDA↓, 1,   NQO1↑, 3,   NRF2↑, 5,   ROS↓, 11,   ROS↑, 1,   mt-ROS↓, 1,   SOD↑, 3,   TAC↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 3,   MMP↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   Acetyl-CoA↑, 2,   AMPK↑, 2,   AMPK⇅, 1,   ECAR↓, 1,   FAO↑, 1,   FGF21↑, 1,   GlucoseCon↑, 20,   Glycolysis↓, 1,   Glycolysis↑, 3,   H2S↑, 1,   HK2↑, 1,   homoC↓, 1,   NADPH↑, 2,   PDH↑, 1,   PDKs↓, 1,   PFK↑, 1,   PKM2↑, 1,   PPARα↑, 1,  

Cell Death ⓘ

Akt?, 1,   Akt↑, 1,   Apoptosis↓, 1,   iNOS↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 5,   other↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   IGF-1↓, 1,   IGF-1↑, 1,   mTOR↓, 2,   PI3K↑, 2,   PTEN↓, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↓, 1,   MMP9↓, 1,   PKCδ↑, 1,   VCAM-1↓, 3,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   Hif1a↓, 1,   Hif1a↑, 2,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 4,   GLUT3↑, 3,   GLUT4↑, 5,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 9,   NF-kB↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 2,   ChAT↑, 5,   tau↓, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 7,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 3,   Dose↝, 2,   eff↑, 3,   eff↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

BP↝, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 12,   hepatoP↑, 1,   memory↑, 8,   motorD↑, 1,   neuroP↑, 11,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   Weight↓, 1,  
Total Targets: 109

Scientific Paper Hit Count for: GlucoseCon, Glucose Consumption
11 Alpha-Lipoic-Acid
2 diet Methionine-Restricted Diet
2 Methylene blue
2 Vitamin B1/Thiamine
2 Vitamin K2
1 Betulinic acid
1 Ivermectin
1 Orlistat
1 Phosphatidylserine
1 Rosmarinic acid
1 Vitamin B2,Riboflavin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:623  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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