COMT Cancer Research Results

COMT, catechol-O-methyl transferase: Click to Expand ⟱
Source:
Type:
Catechol-O-methyltransferase (COMT) is an enzyme located in the frontal cortex of the brain that metabolizes epinephrine, norepinephrine, and dopamine.
Genetic polymorphisms in the COMT gene can influence enzyme activity and may be associated with the risk of certain cancers.
COMT is involved in the metabolism of estrogens, particularly catechol estrogens, which can have both proliferative and genotoxic effects on breast tissue. Dysregulation of estrogen metabolism has been implicated in the development of hormone-related cancers.
Scientific Papers found: Click to Expand⟱
3193- SFN,    Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
- Review, Var, NA
DNMTs↓, SFN, a natural phytochemical, primarily attenuates both DNMTs and HDACs, individually suppressing DNA hypermethylation and histones deacetylation, ultimately upregulating NRF2.
HDAC↑,
NRF2↑,
DNMT1↓, significant attenuation of DNMT1 and DNMT3a contributed to a decrease in the methylated CpG ratio in the NFE2L2 promoter region in an SFN dose- and time-dependent manner, thus increasing NRF2
DNMT3A↓,
NQO1↑, consequently increasing the transcription of its target genes such as NQO1 and catechol-O-methyltransferase (COMT)
COMT↑,
TumCG↓, SFN may prevent or slow the growth of recurrent prostate cancer, essentially without severe adverse events.
*toxicity↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NQO1↑, 1,   NRF2↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↑, 1,   TumCG↓, 1,  

Hormonal & Nuclear Receptors ⓘ

COMT↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: COMT, catechol-O-methyl transferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:64  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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