FTH1 Cancer Research Results
FTH1, ferritin heavy chain: Click to Expand ⟱
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Ferritin is a protein that stores iron in the body and is made up of two subunits, ferritin light chain (FTL) and ferritin heavy chain (FTH1).
Ferritin heavy chain 1 (FTH1) is one of the two subunits that make up the protein ferritin, which is responsible for storing iron in the body. FTH1 is encoded by the FTH1 gene, which is located on chromosome 11 in humans.
FTH1 expression is often upregulated in various cancers and is generally associated with a poorer prognosis.
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Scientific Papers found: Click to Expand⟱
*Beclin-1↑, autophagy-related markers Beclin1 and LC3B were upregulated and P62 was downregulated after BBR treatment.
*LC3B↑,
*p62↓,
*ROS↓, ROS and lipid peroxide MDA decreased significantly after BBR treatment.
*lipid-P↓,
*MDA↓,
*Ferroptosis↓, expression levels of ferroptosis-related genes TFR1, ASCL4, DMT1, and IREB2 were decreased, while the expression levels of FTH1 and SLC7A11 increased after BBR treatment.
*TfR1/CD71↓,
*FTH1↑,
*memory↑, BBR treatment enhanced spatial memory impairment in 5xFAD mice.
*JNK↓, inhibited ferroptosis by inhibiting the JNK-P38MAPK signaling pathway.
*p38↓,
*Aβ↓, further reducing Aβ plaque deposition, inhibiting inflammatory response,
*Inflam↓,
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in-vitro, |
BC, |
MCF-7 |
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in-vitro, |
BC, |
MDA-MB-231 |
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Ferroptosis↑,
Iron↑,
ROS↑,
lipid-P↑,
MDA↑,
GSH↓,
HO-1↑, Curcumin upregulates a variety of ferroptosis target genes related to redox regulation, especially heme oxygenase-1 (HO-1).
NRF2↑,
GPx↓,
ROS↑,
Iron↑, curcumin caused marked accumulation of intracellular iron
GPx4↓,
HSP70/HSPA5↑,
ATFs↑, ATF4
CHOP↑, DDIT3
MDA↑,
FTL↑, Curcumin upregulated FTL (encoding ferritin light chain), FTH1
FTH1↑,
BACH1↑,
REL↑, v-rel reticuloendotheliosis viral oncogene homolog A
USF1↑,
NFE2L2↑,
*cardioP↑, thymoquinone can alleviate doxorubicin-induced cardiac toxicity in mice.
*NRF2↑, alleviate iron death in mouse cardiomyocytes by activating the Nrf2/HO-1 signaling pathway
*HO-1↑,
*ROS↓, Thymoquinone can also alleviate oxidative stress in mouse cardiomyocytes
*NQO1↑, similar effects on the expression levels of NQO1, COX-2, and NOX4
*COX2↓, implied
*NOX4↓, implied
*GPx4↑,
*FTH1↑, Reduces free iron, limiting ferroptosis
*p‑mTOR↓,
*TGF-β↓,
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, GPx↓, 1, GPx4↓, 1, GSH↓, 1, HO-1↑, 1, Iron↑, 2, lipid-P↑, 1, MDA↑, 2, NFE2L2↑, 1, NRF2↑, 1, ROS↑, 2,
Metal & Cofactor Biology ⓘ
FTH1↑, 1, FTL↑, 1,
Cell Death ⓘ
Ferroptosis↑, 1,
Transcription & Epigenetics ⓘ
USF1↑, 1,
Protein Folding & ER Stress ⓘ
ATFs↑, 1, CHOP↑, 1, HSP70/HSPA5↑, 1,
Migration ⓘ
BACH1↑, 1,
Angiogenesis & Vasculature ⓘ
REL↑, 1,
Total Targets: 20
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↓, 1, GPx4↑, 1, HO-1↑, 1, lipid-P↓, 1, MDA↓, 1, NOX4↓, 1, NQO1↑, 1, NRF2↑, 1, ROS↓, 2,
Metal & Cofactor Biology ⓘ
FTH1↑, 2, TfR1/CD71↓, 1,
Cell Death ⓘ
Ferroptosis↓, 1, JNK↓, 1, p38↓, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↑, 1, LC3B↑, 1, p62↓, 1,
Proliferation, Differentiation & Cell State ⓘ
p‑mTOR↓, 1,
Migration ⓘ
TGF-β↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, Inflam↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1,
Functional Outcomes ⓘ
cardioP↑, 1, memory↑, 1,
Total Targets: 24
Scientific Paper Hit Count for: FTH1, ferritin heavy chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:646 State#:% Dir#:2
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