Fibronectin Cancer Research Results

Fibronectin, Fibronectin: Click to Expand ⟱
Source:
Type:
Fibronectin is a high-molecular weight glycoprotein that plays a crucial role in cell adhesion, migration, and tissue repair. It is a key component of the extracellular matrix (ECM) and is involved in various cellular processes, including cell signaling, differentiation, and survival. Studies have shown that fibronectin is overexpressed in various types of cancer, including breast, lung, colon, and ovarian cancer. High levels of fibronectin have been associated with poor prognosis and reduced survival in cancer patients.
Scientific Papers found: Click to Expand⟱
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
PD-L1↑, resveratrol dose-dependently upregulates PD-L1 expression at the range of pharmacologic-achievable concentrations in lung cancer cells
Snail↑, resveratrol dose-dependently increased Snail levels in association with the suppression of E-cadherin protein levels, as well as induction of N-cadherin, Fibronectin and Vimentin levels
E-cadherin↓,
N-cadherin↑, induction of N-cadherin, Fibronectin and Vimentin levels
Fibronectin↑,
Vim↑,
Axin2↓, Snail in turn inhibits transcription of Axin2


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

Axin2↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   Fibronectin↑, 1,   N-cadherin↑, 1,   Snail↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↑, 1,  

Clinical Biomarkers ⓘ

PD-L1↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Fibronectin, Fibronectin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:654  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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