Albumin Cancer Research Results

Albumin, Albumin: Click to Expand ⟱
Source:
Type: protein
Albumin is a protein found in the blood that plays a crucial role in maintaining various bodily functions, including blood volume, blood pressure, and the transport of hormones, vitamins, and minerals.
Associated with improved prognosis in certain types of cancer.
May be a marker of improved nutritional status and reduced inflammation in cancer patients.
Albumin is the most abundant plasma protein, synthesized by the liver. Biologically, it maintains oncotic pressure, transports hormones/drugs, and buffers redox and metabolic stress.

In oncology, serum albumin is a host-state biomarker, not a tumor marker.

What Low Albumin Means in Cancer
-Hypoalbuminemia reflects a convergence of cancer-relevant processes:
-Chronic inflammation (IL-6 suppresses hepatic albumin synthesis)
-Catabolism and cachexia
-Poor nutritional reserve
-Liver synthetic stress
-Advanced systemic disease

Low albumin is therefore a global severity signal, not a single-pathway readout.


Scientific Papers found: Click to Expand⟱
438- CUR,    Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats
- vitro+vivo, CRC, CC531
TumCP↓, >30% 48hr
TumVol↓, 5.6 fold
Albumin↑,
ALP↑,
AST↑,
ALAT↑,
cholinesterase↓,

4445- SeNPs,  DFE,    A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- in-vivo, LiverDam, NA
*hepatoP↑, This study suggests that CCL4-induced liver damage in rats can be protected by administration whether the costly SeNPs or the economical DFE.
*antiOx↑, Selenium (Se) is considered as one of the most beneficial elements on the human health, such as performing as antioxidant and anticancer supplement it regulates the functions of selenoproteins which could reduce the tissue oxidation and balancing the
*AntiCan↑,
*BioAv↑, Selenium nanoparticles (SeNPs) have a high bioavailability and proper biological activities, as its greater surface area, better absorption, minimal toxicity and increasing bioactivity so it is used widely in biomedicine
*toxicity↓,
*ROS↓, The fact that Se has a hepatoprotective effect is usually attributed to its antioxidant ability to limit the tissue oxidation by decreasing the ROS.
*MDA↓, significantly reduced in the SeNPs and DFE groups to levels comparable to the control group.
*ALAT↓, in the current study by consumption of SeNPs or DFE showed a significant decrease in the ALT and increase in albumin blood levels indicating their hepatoprotective properties
*Albumin↑,
*GSH↑, In the current study, the SeNPs group showed a statistically increased in the tissue antioxidants GSH and SOD while in DFE group there was a moderate increas
*SOD↑,
*RenoP↑, dates have anti-inflammatory, immune-stimulating, anti-hyperglycemic, anti-cholesterol, antioxidant, and reno-protective characteristics

2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, parallel significant restoration of the serum total protein and albumin by 1.1- and 1.13-fold
*AST↓, VK2 administration reversed this situation, as confirmed by the significant decrease in serum ALT and AST by 0.25- and 0.27-fold
*ALAT↓,
*Keap1↓, significant decrease in Keap-1 mRNA by 0.32-fold
*NRF2↑, significant restoration of the Nrf-2 mRNA level
*HO-1↑,
*COX2↓, VK2 administration to aged animals attenuated hepatic inflammation where hepatic sections from aged-treated rats demonstrated a marked downregulation in COX-2, iNOS and TNF-α
*iNOS↓,
*TNF-α↓,
*TIMP1↓, VK2-treated aged rats showed a significant downregulation in both hepatic TIMP-1 concentration and TGF-β immunostaining compared to the aged untreated control
*TGF-β↓,
*ROS↓, Emerging evidence reported Nrf-2 signaling and VK to play a crucial role in counteracting oxidative stress, DNA damage, senescence and inflammation. These events help in quenching ROS
*DNAdam↓,
*Inflam↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ALAT↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Synaptic & Neurotransmission ⓘ

cholinesterase↓, 1,  

Clinical Biomarkers ⓘ

ALAT↑, 1,   Albumin↑, 1,   ALP↑, 1,   AST↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   Keap1↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,  

Cell Death ⓘ

iNOS↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

TGF-β↓, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   Albumin↑, 2,   AST↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   hepatoP↑, 1,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 24

Scientific Paper Hit Count for: Albumin, Albumin
1 Curcumin
1 Selenium NanoParticles
1 Date Fruit Extract
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:690  State#:%  Dir#:2
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