AST Cancer Research Results

AST, Aspartate Aminotransferase: Click to Expand ⟱
Source:
Type:
AST (Aspartate Aminotransferase) is an enzyme found in various tissues throughout the body, including the liver, heart, muscles, kidneys, and brain. Elevated levels of AST in the blood can be an indicator of tissue damage or disease.
AST levels can be elevated in certain types of cancer.
Used as a clinical biomarker for Liver function


Scientific Papers found: Click to Expand⟱
438- CUR,    Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in Rats
- vitro+vivo, CRC, CC531
TumCP↓, >30% 48hr
TumVol↓, 5.6 fold
Albumin↑,
ALP↑,
AST↑,
ALAT↑,
ChE↓,

6781- EGCG,    Scientific opinion on the safety of green tea catechins
- Review, Nor, NA
*hepatoP↓, rare cases of liver injury have been reported after consumption of green tea infusions, most probably due to an idiosyncratic reaction.
*Dose↝, intake of doses equal or above 800 mg EGCG/day taken as a food supplement has been shown to induce a statistically significant increase of serum transaminases in treated subjects compared to control.
*ALAT↑, above 800 mg EGCG/day for 4 months or longer are associated with elevations of ALT and AST in a small percentage (usually less than 10%) of the population.
*AST↑,

7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, orally applied gossypol/AT-101 at low doses (30 mg daily or lower) was determined as well tolerable either as monotherapy or in combination with chemo-radiation.
toxicity↓,
PFS↓, Within these trials, a potential benefit was observed in high-risk patients or in some patients with prolongation in progression-free survival or in overall survival.
OS↑,
eff↑, most recent clinical trial combined low dose AT-101 with docetaxel, fluorouracil, and radiation, achieving complete responses in 11 of 13 patients with gastroesophageal carcinoma (median duration of 12 months) and a median progression-free survival o
BioAv↑, The gossypol (−)-enantiomer—also called AT-101—is degraded more slowly and is therefore the more biologically active form
Bcl-2↓, AT-101, a natural Bcl-2 homology domain 3 (BH3) mimetic, is a small molecule inhibitor that downregulates anti-apoptotic Bcl-2 and Bcl-2-related proteins in human cancer cells
ROS↑, In addition, gossypol-induced intrinsic apoptosis might occur also as reactive oxygen species (ROS)-independent
MOMP↑, In gossypol-treated cancer cells, alterations on the mitochondrial outer membrane permeabilization (MOMP) cause the release of large amounts of apoptotic markers, such as cytochrome c and apoptosis-inducing factor (AIF),
Dose↑, Thereby, the maximum tolerated gossypol dose was determined to be 0.8 mg/kg per day (50–60 mg/day),
Casp3↑, Gossypol-induced apoptosis appears to proceed via the caspase-dependent pathway by activation of caspase-3 and caspase-9
Casp9↑,
MMP↑, as well as mitochondrial membrane depolarization
VEGF↓, suppression of vascular endothelial growth factor (VEGF) stimulating intracellular pro-angiogenic kinases phosphorylation could be inhibited by AT-101
APE1/APEX1↓, addition of gossypol leads to inhibition of APE1 and enhances the activity of cisplatin in non-small cell lung cancer
ChemoSen↑,
RadioS↑, Moreover, AT-101 was demonstrated to radiosensitize prostate cancer in vitro and in vivo without augmenting toxicity
toxicity↑, hematologic toxicities are common treatment related toxicities
AST↑, he majority of related AEs were GI and nervous system disorders, increased AST/ALT, of grade 1/2 toxicities
ALAT↑,

7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, However, IBC causes some hepatotoxicity, and the mechanism of toxicity is unclear.
*ALAT↑, exposure to IBC increased zebrafish embryo mortality and decreased hatchability. Meanwhile, IBC induced liver injury and increased expression of ALT and AST activity.
*AST↑,
*ROS↑, IBC caused the increase of ROS and MDA the decrease of CAT, GSH, and GSH-Px; the increase of Fe2+ content; and the changes of ferroptosis related genes (acsl4, gpx4, and xct) and iron storage related genes (tf, fth, and fpn) in zebrafish embryos.
*MDA↑,
*Catalase↓,
*GSH↓,
*GPx↓,
*i-Iron↑,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   PFS↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 2,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   MOMP↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 2,   Albumin↑, 1,   ALP↑, 1,   AST↑, 2,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   toxicity↓, 1,   toxicity↑, 1,   TumVol↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↓, 1,   GSH↓, 1,   i-Iron↑, 1,   MDA↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 2,   AST↑, 2,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↓, 2,  
Total Targets: 11

Scientific Paper Hit Count for: AST, Aspartate Aminotransferase
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Gossypol/AT-101
1 Isobavachalcone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:691  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page