TIM-3 Cancer Research Results

TIM-3, T-cell immunoglobulin and mucin-domain containing-3: Click to Expand ⟱
Source:
Type: protein
TIM-3 is a protein that plays a crucial role in the regulation of the immune system. It is expressed on the surface of certain immune cells, including T cells and macrophages.

TIM-3 has been identified as a potential biomarker and therapeutic target. TIM-3 is often overexpressed on the surface of tumor-infiltrating T cells and other immune cells in various types of cancer, including melanoma, lung cancer, and breast cancer.

The overexpression of TIM-3 on immune cells in the tumor microenvironment can contribute to immune suppression and tumor progression. TIM-3 can bind to its ligand, galectin-9, which is expressed on the surface of tumor cells. This binding can lead to the inhibition of T-cell function and the promotion of T-cell exhaustion, allowing the tumor to evade immune surveillance.
Scientific Papers found: Click to Expand⟱
1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, NA, NA
eff↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

Ki-67↑, 1,   L-sel↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Cellular Microenvironment ⓘ

TIM-3↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↑, 1,   PD-L1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TIM-3, T-cell immunoglobulin and mucin-domain containing-3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:710  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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