p73 Cancer Research Results

p73, p73: Click to Expand ⟱
Source:
Type: protein
p73 is a protein that plays a crucial role in regulating cell growth, differentiation, and death. It is a member of the p53 family of proteins, which are known as tumor suppressors.
p73 is often inactivated or downregulated in various types of cancer, including breast, lung, and brain cancer.
Scientific Papers found: Click to Expand⟱
476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
TumCMig↓,
TumCI↓,
Apoptosis↑,
NEDD9↓,
p‑Akt↓,
p‑mTOR↓,
PTEN↑,
p73↑,
β-TRCP↑,

6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, Diclofenac is a highly prescribed non-steroidal anti-inflammatory drug (NSAID) that relieves inflammation, pain, fever, and aches, used at different doses depending on clinical conditions.
*Pain↓,
*COX1↓, This drug inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, which are responsible for the generation of prostaglandin synthesis.
*COX2↓,
*toxicity↝, critical challenge that appears with diclofenac and other drugs of the same class is their side effects, such as signs of stomach injuries, kidney problems, cardiovascular issues, hepatic issues, and diarrhea.
*BioAv↑, The potassium salt of diclofenac was developed to increase the rate of diclofenac absorption, which could be used in conditions where rapid pain relief is needed
*AntiAg↑, diclofenac’s inhibitory effect on platelet aggregation has also been reported
*neuroP↑, Neuroprotective Abilities of Diclofenac
ROS↑, inhibiting proliferation of cancer cells have also been reported, as shown in Figure 3, indicating its dual role. These mechanisms include inhibition of proteasomes [72], enhancement of ROS production [111], increase in p73 activity [112], and inhibi
p73↑,
Myc↓, inhibition of MYC expression and lactate transport
lactateProd↓,
TumCCA↑, Diclofenac is found to obstruct cell cycle in different cell lines, such as neural stem cells, human lymphatic endothelial cells (HLEC), osteoblasts, glioblastomas (GBM), ovarian cells, and VSMC.
PI3K↓, diclofenac-mediated apoptosis includes ROS-induced downregulation of the PI 3-kinase/Akt signaling pathway, inhibition of NF-kB activity, disturbance in proteasome activity
Akt↓,
NF-kB↓,
SOD2↓, Diclofenac impedes both expression levels and enzyme actions of SOD2
*neuroP↑, Recently, diclofenac as a curcumin adjuvant has been shown to aid anti-Alzheimer effects of curcumin in mice


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   SOD2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

lactateProd↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   Myc↓, 1,   β-TRCP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p73↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

NEDD9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 2,   Pain↓, 1,   toxicity↝, 1,  
Total Targets: 8

Scientific Paper Hit Count for: p73, p73
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:750  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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