MMP3 Cancer Research Results

MMP3, Matrix metalloproteinase-3: Click to Expand ⟱
Source:
Type:
MP-3: also known as stromelysin-1, is a type of enzyme that plays a crucial role in the degradation of the extracellular matrix (ECM).
MMP-3 can break down the ECM, allowing cancer cells to invade surrounding tissues and form new tumors.
High levels of MMP-3 expression are associated with poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
4382- AgNPs,    Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
- in-vitro, Nor, RAW264.7
*GSH↓, AgNPs decreased intracellular glutathione level, increased NO secretion, increased TNF-α in protein and gene level
*NO↑,
*TNF-α↑,
*MMP3↑, increased gene expression of matrix metalloproteinases (MMP-3, MMP-11, and MMP-19).
*MMP11↑,

498- MF,    Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study
- in-vitro, NA, NA
Calcium↑,
MMP1↑, 2.8x
MMP3↑, 2.1x
BMPs↑, BMP-2 increase untill after day 9

2971- PL,    Piperlongumine attenuates IL-1β-induced inflammatory response in chondrocytes
- NA, OS, NA
*NO↓, PLM significantly inhibited the production of NO and PGE2, iNOS and COX-2 expression, as well as suppressed the production of MMP-3 and MMP-13 in IL-1β-stimulated human OA chondrocytes
*PGE2↓,
*iNOS↓,
*COX2↓,
*MMP3↑,
*MMP13↓,
*Inflam↓, PLM may serve as a potential anti-inflammatory agent in the treatment of OA


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

MMP1↑, 1,   MMP3↑, 1,  

Clinical Biomarkers ⓘ

BMPs↑, 1,   Calcium↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Migration ⓘ

MMP11↑, 1,   MMP13↓, 1,   MMP3↑, 2,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   NO↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   PGE2↓, 1,   TNF-α↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: MMP3, Matrix metalloproteinase-3
1 Silver-NanoParticles
1 Magnetic Fields
1 Piperlongumine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:757  State#:%  Dir#:2
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