VGCC Cancer Research Results

VGCC, Voltage-gated calcium channels: Click to Expand ⟱
Source:
Type: transmembrane proteins
VGCCs play a crucial role in various cellular processes, including cell signaling, proliferation, and differentiation.
VGCCs are transmembrane proteins that regulate the influx of calcium ions into cells. Calcium ions act as a second messenger, triggering various signaling pathways that control cell growth, survival, and migration. In cancer cells, VGCCs can be overexpressed or mutated, leading to aberrant calcium signaling and contributing to tumor growth and metastasis.
Overexpressed in: breast cancer, prostate cancer, colorectal cancer, glioblastoma Associated with: tumor growth, metastasis, and poor prognosis.
Scientific Papers found: Click to Expand⟱
5530- EP,    Expression of voltage-gated calcium channels augments cell susceptibility to membrane disruption by nanosecond pulsed electric field
- in-vitro, Nor, HEK293
*CellMemb↑, 300-ns pulses at 1.8 and 2.3 kV/cm caused permeabilization in HEK2913 cells. Exposure at 2.3 kV/cm caused permeabilization in all cells tested.
*VGCC↑, Voltage-gated Ca2+ channels (VGCC) are one of the major transmembrane pathways for Ca2+ to enter the cell.These channels are activated by membrane depolarization,
*Ca+2↑, ability of nsPEF to elevate cytosolic Ca2+ by nanopore opening could become a promising approach for non-chemical triggering of Ca2+-signaling in various cell types.
*MMP↓, These channels are activated by membrane depolarization,
*VGCC⇅, Aside from the immediate VGCC activation by membrane depolarization, nsPEF-treated cells experienced a long-lasting inhibition of VGCC
eff↑, Permeabilization by nsPEF is stronger in cells which express more VGCC

5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, leading to an incremental increase in cytoplasmic Ca2+ concentration,
Apoptosis↑, from apoptosis up to cell differentiation and proliferation.
Diff↑,
TumCP↓,
Wound Healing↑, sterilization in the food industry, seed germination, anti-parasitic effects, wound healing, increased immune response
CellMemb↑, available evidence suggest that the increase in cytoplasmic Ca2+ concentration produced by the application of nsPEF could be due to the formation of membrane nanopores.
VGCC↑, most probable cause should be the increase of intracellular Ca2+ concentration via VGCC activation [185].
VGSC↑, findings relating VGNC activation by nsPEF are exciting and deserve more attention.
DNAdam↑, Stacey et al. in 2002 demonstrated that exposing cancer cells to nsPEF with 60 kV/cm could induce DNA damage [243]
selectivity↑, More importantly for nsPEF as cancer treatment, tumor cells are more sensitive to nsPEF than normal cells [246].

2238- MF,    Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
- Review, Var, NA
*BMD↑, Therapeutic bone-growth stimulation via Ca2+/nitric oxide/cGMP/protein kinase G. Multiple studies have implicated increased Ca2+ and nitric oxide in the EMF stimulation of bone growth
*VGCC↑, increased VGCC activity following EMF exposure and suggests, therefore, that VGCC stimulation in the plasma membrane is directly produced by EMF exposure.
*Ca+2↑, Other studies, each involving VGCCs, summarized in Table 1, also showed rapid Ca2+ increases following EMF exposure [8, 16, 17, 19, 21].
*NO↑, Multiple studies have implicated increased Ca2+ and nitric oxide in the EMF stimulation of bone growth
*eff↓, Voltage-gated calcium channel stimulation leads to increased intracellular Ca2+, which can act in turn to stimulate the two calcium/calmodulin-dependent nitric oxide synthases and increase nitric oxide.

499- MF,    The Effect of Pulsed Electromagnetic Fields on Angiogenesis
- Review, NA, NA
angioG↑, normal tissue
VEGF↑, normal tissue
VGCC↑, normal tissue


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   VGCC↑, 2,   VGSC↑, 1,  

Migration ⓘ

Ca+2↑, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

Wound Healing↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGCC↑, 2,   VGCC⇅, 1,  

Migration ⓘ

Ca+2↑, 2,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: VGCC, Voltage-gated calcium channels
2 Electrical Pulses
2 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:758  State#:%  Dir#:2
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