CYP1A1 Cancer Research Results

CYP1A1, Cytochrome P450 1A1: Click to Expand ⟱
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Type:
CYP1A1 (Cytochrome P450 1A1) is an enzyme that plays a significant role in the metabolism of various substances, including drugs, environmental pollutants, and procarcinogens. It is part of the cytochrome P450 family of enzymes, which are involved in the oxidative metabolism of a wide range of compounds.

Role in Cancer
Activation of Procarcinogens: CYP1A1 is known to convert certain procarcinogenic compounds, such as polycyclic aromatic hydrocarbons (PAHs) found in tobacco smoke and grilled meats, into their active forms. These metabolites can bind to DNA and form adducts, leading CYP1A1 expression is a significant factor in the context of various cancers, particularly those associated with environmental and lifestyle factors. to mutations and potentially initiating cancer.
Scientific Papers found: Click to Expand⟱
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↑, 4,   CYP2E1↑, 1,   GSH↓, 2,   lipid-P↓, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 1,   OCR↓, 1,   e-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 1,   FASN↓, 1,   GLO-I↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,   DR4↑, 1,   Fas↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   p38↓, 1,   survivin↓, 2,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,   HER2/EBBR2↓, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   ERK↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   RAS↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration ⓘ

AntiAg↑, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   STAC2↓, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 4,   TumMeta↓, 2,   VCAM-1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   JAK↓, 1,   NF-kB↓, 2,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 4,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 1,   Dose↝, 1,   eff↑, 1,   P450↓, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   HER2/EBBR2↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   Risk↓, 1,  
Total Targets: 87

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   CYP1A1↑, 1,   GPx1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis ⓘ

CYP2C6↑, 1,   CYP3A2↑, 1,  

Cell Death ⓘ

AhR↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Migration ⓘ

Ca+2↓, 1,   CYP2D1↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   CYP1A2↑, 1,   Dose↝, 2,   Half-Life↝, 1,  

Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 20

Scientific Paper Hit Count for: CYP1A1, Cytochrome P450 1A1
1 Chocolate
1 Emodin
1 Naringin
1 Phenethyl isothiocyanate
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:76  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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