miR-200c Cancer Research Results

miR-200c, miR-200c: Click to Expand ⟱
Source:
Type: tumour-suppressor miRNA
miR-200c studied particularly in the regulation of epithelial-to-mesenchymal transition (EMT) and cancer metastasis.
miR-200c is a member of the miR-200 family, which includes miR-200a, miR-200b, and miR-200c. These miRNAs are known to play a crucial role in maintaining epithelial cell identity and suppressing EMT, a process by which epithelial cells acquire a mesenchymal phenotype and become more migratory and invasive.

miR-200c has been shown to target several genes involved in EMT and cancer progression, including:

     ZEB1 and ZEB2, transcription factors that promote EMT and cancer metastasis.
     TGF-β, a cytokine that promotes EMT and cancer progression.
     Vimentin, a protein that is highly expressed in mesenchymal cells and is associated with cancer metastasis.

The overexpression of miR-200c has been shown to inhibit EMT and cancer metastasis in various types of cancer, including breast, lung, and ovarian cancer. Conversely, the downregulation of miR-200c has been associated with cancer progression and poor prognosis.

Downregulated in: lung, CRC, GC, pancreatic, HCC (associated with poor prognosis).
Scientific Papers found: Click to Expand⟱
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR‐34, miR‐126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a
miR-200c↑,
miR-409-3p↑,
miR-34a↑,
miR-126↑,
miR-145↑,
miR-206↑,
miR-491↑,
miR-141↑,
miR-429↑,
miR-101↑,
miR-15↑,
miR-21↓, and the downregulation of miR-21, miR-155, miR‐221, miR‐222, miR-17-5p, miR-130a, miR-27, and miR-20a.
miR-155↓,
miR-221↓,
miR-222↓,
miR-17↓,
miR-130a↓,
miR-27a-3p↓,
miR-20↓,

679- EGCG,  5-FU,    Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer
- in-vitro, CRC, NA
NOTCH1↓, Furthermore, EGCG suppressed Notch1
BMI1↓,
SUZ12↓,
EZH2↓,
miR-34a↑,
miR-200c↑,
miR-145↑,
CSCs↓, (EGCG), an active catechin present in green tea, has been shown to suppress CSC growth in various cancers

7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature.
Inflam↓,
AntiCan↑,
NF-kB↓, Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo.
STAT3↓,
antiNeop↑, Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc.
5LO↓, ability of garcinol to bind and inhibit 5-lipoxygenase (5-Lox),
eff↑, . The addition of 10 % FBS (fetal bovine serum) to medium leads to approximately 10-fold decrease in IC 50 value of garcinol for HCT116 cell growth.
HATs↓, Garcinol has been demonstrated to inhibit HATs such as p300 and PCAF both in vitro and in vivo
p300↓,
PCAF↓,
miR-200c↑, Garcinol treatment has been shown to cause upregulation of several tumor suppressor miRNAs, of which miR-200c was found to target and downregulate Notch1 in pancreatic CSCs
NOTCH1↓,
CSCs↓,
COX2/PTGS2↓, garcinol has been shown to cause significant reduction in expression level of cyclooxygenase-2 (COX-2), cyclin D1, and vascular endothelial growth factor
cycD1/CCND1↓,
VEGF↓,
PI3K↓, via inhibition of the extracellular signal-regulated protein kinase 1/2, PI3K/Akt and Wnt/b-catenin
Akt↓,
Wnt↑,
β-catenin/ZEB1↓,
ROS↑, It could lead to accumulation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress modulator GADD153
CHOP/DDIT3↑,
Bax:Bcl2↑, increased Bax2/Bcl-2 ratio, elevated tBid (truncated Bid), and caspase 8 in cancer cell.
Casp8↑,
FAK↓, garcinol can lead to inhibition of tyrosine phosphorylation of focal adhesion kinase (FAK),
*neuroP↑, garcinol being considered in development of therapeutics for neurodegenerative diseases such as Alzheimers’s, Parkinson’s to attenuate oxidative stress-induced neurotoxicity.
PCNA↓, Significant reduction in proliferating cell nuclear antigen (PCNA) index in ACF was also observed with gar- cinol treatment
*GSTs↑, Garcinol administration in such cases was also seen to enhance activities of liver glutathione S-transferase (GST) and quinone reductase (QR), which play an important role in detoxification process of body

800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, reverses epithelial-to-mesenchymal transition (EMT), that is, it induces mesenchymal-to-epithelial transition (MET)
MET↑,
E-cadherin↑,
Vim↓,
Zeb1↓,
ZEB2↑,
miR-200c↑, miR-200
Let-7↑,
p‑β-catenin/ZEB1↓, garcinol was found to inhibit NF-κB, miRNAs, vimentin, and nuclear β-catenin
NF-kB↓,

816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓,
EZH2↓,
ABCG2↓,
Gli1↓,
NOTCH1↓,
miR-200c↑, miR-200c increased by garcinol treatment was found to target and downregulate Notch1.

1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, NA, NA
HDAC↓, 15 μM
HDAC1↓,
HDAC2↓,
HDAC3↓,
HDAC8↓,
eff↑, this evidence suggests that sulforaphane may also compromise DNA repair mechanisms in cancer cells with selectivity.
ac‑HSP90↑,
DNMT1↓, 10 μM sulforaphane in 6 days inhibited DNMT1 and DNMT3a expression by 48% and 78%, respectively
DNMT3A↓,
hTERT/TERT↓,
NRF2↑, enhance nuclear translocation of Nrf2 and increase expression of Nrf2-target antioxidant genes, including HO-1, NQO1, and UGT1A1
HO-1↑,
NQO1↑,
miR-155↓,
miR-200c↑,
SOX9↓,
*toxicity↓, broccoli sprout-infused beverage containing 400 μM glucoraphanin nightly for 2 weeks causing no adverse effects and being well tolerated in 200 subjects


Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bax:Bcl2↑, 1,   Casp8↑, 1,   hTERT/TERT↓, 1,   Mcl-1↓, 1,   miR-497↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 2,   HATs↓, 1,   miR-145↑, 2,   miR-21↓, 1,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,   PCAF↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ac‑HSP90↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   CSCs↓, 2,   EMT↓, 1,   Gli1↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   Let-7↑, 1,   miR-101↑, 1,   miR-34a↑, 2,   miR-429↑, 1,   NOTCH1↓, 3,   p300↓, 1,   PI3K↓, 1,   STAT3↓, 1,   SUZ12↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   MET↑, 1,   miR-130a↓, 1,   miR-141↑, 1,   miR-155↓, 2,   miR-20↓, 1,   miR-200c↑, 6,   miR-206↑, 1,   miR-221↓, 1,   miR-222↓, 1,   miR-491↑, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↑, 1,   β-catenin/ZEB1↓, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   NF-kB↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

EZH2↓, 2,   hTERT/TERT↓, 1,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTs↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: miR-200c, miR-200c
3 Garcinol
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 5-fluorouracil
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:765  State#:%  Dir#:2
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