miR-126 Cancer Research Results

miR-126, miR-126: Click to Expand ⟱
Source:
Type: tumour-suppressor miRNA
miR-126 is involved in the regulation of angiogenesis, which is the process of forming new blood vessels.
miR-126 is downregulated in many types of cancer, including breast, lung, colon, and pancreatic cancer.
The downregulation of miR-126 has been associated with poor prognosis and increased metastasis in cancer patients.
Scientific Papers found: Click to Expand⟱
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
miR-126↑, boric acid could induce miR-127-5p expression
COL1A1↓,
Vim↓,
Zeb1↑, expression of the miR-127-5p, ZEB1, CDH1, ITGB1, ITGA5, LAMA5, and SNAIL, was up-regulated in dose-treated BC-SCs
CDH1↑,
ITGB1↑,
ITGA5↑,
LAMA5↑,
Snail↑,
miR-127-5p↑,

5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, The inhibitory concentration of capsaicin for HepG2 cells was 200 nM and the decreased proliferation was observed at 24th hour.
miR-126↑, up regulation of miR-126 and down regulation of piR-Hep-1 expression were determined after treatment.
Ki-67↓, Moreover, Ki-67, PI3K and mTOR gene expressions decreased while AKT gene expression increased after the treatment
PI3K↓,
mTOR↓,
Akt↑,
eff↑, It is worth noting that utilizing a static magnetic field (SMF), capsaicin affinity to the TRPV1 receptor may be boosted, improving capsaicin's anti-cancer impact on HepG2 cells via caspase-3 death (8).
Casp3↑,

4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR‐34, miR‐126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a
miR-200c↑,
miR-409-3p↑,
miR-34a↑,
miR-126↑,
miR-145↑,
miR-206↑,
miR-491↑,
miR-141↑,
miR-429↑,
miR-101↑,
miR-15↑,
miR-21↓, and the downregulation of miR-21, miR-155, miR‐221, miR‐222, miR-17-5p, miR-130a, miR-27, and miR-20a.
miR-155↓,
miR-221↓,
miR‐222↓,
miR-17↓,
miR-130a↓,
miR-27a-3p↓,
miR-20↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↑, 1,   Casp3↑, 1,   miR-127-5p↑, 1,   miR-497↑, 1,  

Transcription & Epigenetics ⓘ

miR-145↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

miR-101↑, 1,   miR-34a↑, 1,   miR-429↑, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

CDH1↑, 1,   COL1A1↓, 1,   ITGA5↑, 1,   ITGB1↑, 1,   Ki-67↓, 1,   LAMA5↑, 1,   miR-130a↓, 1,   miR-141↑, 1,   miR-155↓, 1,   miR-20↓, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-221↓, 1,   miR-491↑, 1,   miR‐222↓, 1,   Snail↑, 1,   Vim↓, 1,   Zeb1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 3,   miR-15↑, 1,   miR-17↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-126, miR-126
1 Boron
1 Capsaicin
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:766  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page