HK2 Cancer Research Results

HK2, Hexokinase 2: Click to Expand ⟱
Source:
Type: enzyme
HK2 (Hexokinase 2) is an enzyme that plays a crucial role in glycolysis, the process by which cells convert glucose into energy. HK2 is a key regulatory enzyme in the glycolytic pathway, and it is primarily expressed in various tissues, including muscle, brain, and cancer cells.
HK2 has been shown to be overexpressed in many types of tumors, including breast, lung, and colon cancer. This overexpression may contribute to the development and progression of cancer by promoting glycolysis and energy production in cancer cells.
HK2 is a key regulatory enzyme in the glycolytic pathway.
HK2 plays a role in the regulation of glucose metabolism in diabetes.
HK2 is involved in the regulation of cell proliferation, apoptosis, and autophagy.

HK2 Inhibitors:
-2DG
-Curcumin
-Resveratrol
-EGCG
-Berberine
-Methyl Jasmonate (MJ)
-Honokiol
Scientific Papers found: Click to Expand⟱
2389- BA,    Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor
- in-vitro, Obesity, 3T3
*ECAR↑, *OCR↓, *p‑AMPK↑, *p‑ACC↑, *Glycolysis↑, *lipidDe↓, *SREBP1↓, *FAO↑, *HK2↑, *PKM2↑, *LDHA↑, *PDKs↓, *ACC↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
*Apoptosis↓, *ROS↓, *antiOx↓, *MMP↑, *GPI↑, *HK2↑, *ALDOA↑, *PKM1↑, *LDHA↑, *PFKL↑,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTs↑, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   HK2↑, 1,   lactateProd↑, 1,   LDHA↑, 1,   PDH↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTORC1↓, 1,   PI3K↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,  

Barriers & Transport ⓘ

GLUT1↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 5,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 1,   HO-1↑, 1,   lipidDe↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   OXPHOS↓, 2,   ROS↓, 3,   mt-ROS↓, 1,   SOD↑, 2,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,   mitResp↓, 1,   MMP↑, 1,   MMP↝, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   p‑ACC↑, 1,   ALDOA↑, 1,   p‑AMPK↑, 1,   ECAR↑, 1,   FAO↑, 1,   FGF21↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 4,   Glycolysis↝, 1,   GPI↑, 1,   H2S↑, 1,   HK2↑, 6,   LDHA↑, 3,   PDKs↓, 1,   PFK↑, 1,   PFKL↑, 3,   PFKM↑, 2,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 5,   PPARα↑, 1,   SIRT2↑, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 2,   IGFR↓, 1,   mTOR↓, 1,  

Migration ⓘ

TumCMig↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   ATF4↑, 1,  

Barriers & Transport ⓘ

GLUT1↑, 2,   GLUT4↑, 2,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,   OS↑, 1,  
Total Targets: 61

Scientific Paper Hit Count for: HK2, Hexokinase 2
2 Magnetic Fields
1 Baicalin
1 diet Methionine-Restricted Diet
1 Quercetin
1 Resveratrol
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:773  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page