BMP2 Cancer Research Results

BMP2, Bone Morphogenetic Protein 2: Click to Expand ⟱
Source:
Type:
BMP2 (Bone Morphogenetic Protein 2) is a member of the TGF-β (Transforming Growth Factor-beta) superfamily, which plays a crucial role in regulating cell growth, differentiation, and apoptosis.
BMP2 is overexpressed in: Osteosarcoma, breast, lung, prostate cancers.
Scientific Papers found: Click to Expand⟱
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, PEMF exposure increased cell proliferation and adhesion
*mTOR↑, PEMFs contribute to activation of the mTOR pathway via upregulation of the proteins AKT, MAPP kinase, and RRAGA, suggesting that activation of the mTOR pathway is required for PEMF-stimulated osteogenic differentiation.
*Akt↑,
*PKA↑, PEMFs increase the activity of certain kinases belonging to known intracellular signaling pathways, such as the protein kinase A (PKA) and the MAPK ERK1/2
*MAPK↑,
*ERK↑,
*BMP2↑, PEMFs stimulation also upregulates BMP2 expression in association with increased differentiation in mesenchymal stem cells (MSCs
*Diff↑,
*PKCδ↓, Decrease in PKC protein (involved on Adipogenesis)
*VEGF↑, Increase on VEGF (involved on angiogenesis)
*IL10↑, PEMF induced a significant increase of in vitro expression of IL-10 (that exerts anti-inflammatory activity)

530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, expression of miR-34b-5p decreased under SEMF stimulation,
*ALP↑, significant upregulation in the relative expression levels of osteogenic markers (ALP, RUNX2, BMP2, OCN, and OPN)
*RUNX2↑,
*BMP2↑,
*OCN↑,
*OPN↑,
*β-catenin/ZEB1↑, protein expression levels of osteogenic makers, including Active-β-catenin, RUNX2, and ALP, were elevated upon SEMFs exposure at 0.4 mT, 0.7 mT, and 1 mT
*STAC2↑, subsequently increasing STAC2 level.
*Diff↑, electromagnetic fields promote the osteogenic differentiation
*BMD↑, low-frequency SEMFs promote osteogenesis

880- RES,    Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
- in-vitro, BC, MDA-MB-231
other↓, reduced tumor formation
TumW↓, 55%
FOXO↑, resveratrol resulted in strong induction of FOXO3a activity
BMP2↑, BMP-2 gene was identified as one of the highly increased genes in resveratrol-treated


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BMP2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

Akt↑, 1,   BMP2↑, 2,   MAPK↑, 1,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 2,   ERK↑, 1,   mTOR↑, 1,   RUNX2↑, 1,  

Migration ⓘ

OPN↑, 1,   PKA↑, 1,   PKCδ↓, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-34b-5p↓, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   BMD↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: BMP2, Bone Morphogenetic Protein 2
2 Magnetic Fields
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:777  State#:%  Dir#:2
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