STAC2 Cancer Research Results

STAC2, SH3 and cysteine-rich domain 2: Click to Expand ⟱
Source:
Type: protein
STAC2 (SH3 and cysteine-rich domain 2) is a a novel voltage-gated calcium channel protein. Overexpressed in: breast, prostate, lung, ost, CRC cancers.
STAC2 also interacts with other signaling pathways to promote cancer progression. For example, STAC2 interacts with the PI3K/AKT signaling pathway to promote cell survival and the NF-κB signaling pathway to promote inflammation and cell proliferation.
target genes of STAC2 include: VEGF, MMPs, BCL-2, Cyclin D1
Scientific Papers found: Click to Expand⟱
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, expression of miR-34b-5p decreased under SEMF stimulation,
*ALP↑, significant upregulation in the relative expression levels of osteogenic markers (ALP, RUNX2, BMP2, OCN, and OPN)
*RUNX2↑,
*BMP2↑,
*OCN↑,
*OPN↑,
*β-catenin/ZEB1↑, protein expression levels of osteogenic makers, including Active-β-catenin, RUNX2, and ALP, were elevated upon SEMFs exposure at 0.4 mT, 0.7 mT, and 1 mT
*STAC2↑, subsequently increasing STAC2 level.
*Diff↑, electromagnetic fields promote the osteogenic differentiation
*BMD↑, low-frequency SEMFs promote osteogenesis


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

BMP2↑, 1,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   RUNX2↑, 1,  

Migration ⓘ

OPN↑, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-34b-5p↓, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   BMD↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: STAC2, SH3 and cysteine-rich domain 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:780  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page