MYPT1 / PPP1R12A Cancer Research Results

MYPT1 / PPP1R12A, Myosin phosphatase target subunit 1: Click to Expand ⟱

Source:

Type:

Myosin phosphatase target subunit 1 (MYPT1; gene symbol PPP1R12A) is the regulatory targeting subunit of myosin light-chain phosphatase. The MYPT1-associated phosphatase complex dephosphorylates regulatory myosin light chain and thereby reduces actomyosin contractility. In cancer, phosphorylation of MYPT1 by Rho-associated kinase commonly inhibits myosin phosphatase activity, resulting in increased MLC phosphorylation, cytoskeletal tension, migration, and invasion. Therefore, phosphorylated MYPT1 ↑ is usually associated with increased ROCK signalling and a pro-migratory phenotype, whereas active MYPT1-mediated phosphatase activity is generally anti-contractile. Gene reference.

Scientific Papers found: Click to Expand⟱

6978-

Form,

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

vitro+vivo,

Nor,

HUVECs

zebrafish

*angioG↑, Formononetin is an isoflavone that has been shown to display estrogenic properties and induce angiogenesis activities.
*VEGF↑, reported that, formononetin in a rat fracture model promoted early fracture healing through stimulating angiogenesis by up-regulating VEGF and Flk-1
*MYPT1 / PPP1R12A↑,
*MMP2↑, Our data showed that formononetin increased the expressions of MMP2 and MMP9 in HUVECs significantly in a time-dependent manner
*MMP9↑,
*p‑MYPT1 / PPP1R12A↑, Formononetin also concurrently increased the phosphorylation of MYPT1, MLC2, LIMK1 and cofilin as shown in Fig. 6A,C
*p‑MLC2/MYL9↑,
*p‑LIMK1↑,
*p‑Cofilin↑,
*ROCK1↑, The role of ERα in the activation of ROCK and MMP2/9 pathways in formononetin-induced stress fiber formation and cell migration in HUVECs

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

p‑LIMK1↑, 1, p‑MLC2/MYL9↑, 1, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1,

Migration(tgid=13) ⓘ

p‑Cofilin↑, 1, MMP2↑, 1, MMP9↑, 1, ROCK1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, VEGF↑, 1,
Total Targets: 10

Scientific Paper Hit Count for: MYPT1 / PPP1R12A, Myosin phosphatase target subunit 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells