CXCR4 Cancer Research Results

CXCR4, Chemokine Receptor Type 4: Click to Expand ⟱
Source:
Type:
Chemokine Receptor Type 4 (CXCR4) is a G protein-coupled receptor that plays a significant role in various physiological processes, including immune responses, hematopoiesis, and organ development. It is also implicated in cancer biology, where it has been associated with tumor progression, metastasis, and the tumor microenvironment.
CXCR4 is often overexpressed in various types of cancers, including breast, lung, prostate, and pancreatic cancers. Its activation can promote tumor cell proliferation and survival.
-CXCR4 proteins associated with metastasis


Scientific Papers found: Click to Expand⟱
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, GA Inhibits Signaling of Nuclear Factor-Kappa B (NF-jB)
PI3K↓, GA Inhibits Phosphatidylinositol 3′-Kinase/Protein Kinase B (PI3K/Akt)
Akt↓,
STAT3↓, table 15.1 GA Inhibits Signal Transducer and Activator of Transcription-3 (STAT-3) Pathways
STAT5↓,
IL6↓,
COX2↓, GA Inhibits COX-2
iNOS↓, GA Inhibits iNOS
MMPs↓,
Src↓, GA Inhibits Src
PKA↓,
CXCR4↑, GA Inhibits Chemokine X-Receptor 4 (CXCR4) and Downstream Signaling Pathways
VEGF↓,
Bcl-2↓, GA Inhibits the Expression of Bcl-2 Family Proteins
Bcl-xL↓,
IAP1↓,
Mcl-1↓,
survivin↓,
cycD1/CCND1↓, GA Inhibits Expression of Cyclin D1
HSP90↓,
HSP70/HSPA5↓,
MAPK↓, GA Inhibits Mitogen-Activated Protein Kinase (MAPK)
HATs↓, GA Inhibits CBP/p300 Histone Aceyltransferase (HAT) and Histone Deacetylase (HDAC)
HDAC↓,
FAK↓, GA Inhibits the Activation of Focal Adhesion Kinase (FAK)
ROS↑, GA Induces the Production of Reactive Oxygen Species (ROS)
MMP7↓, GA Inhibits Matrix Metalloproteinase 7 & 9 (MMP-7 & 9)
MMP9↓,
α-tubulin↑, GA Inhibits Tubulin
cl‑PARP↑, GA Induces Cleavage of Poly(ADP-Ribose) Polymerases (PARPs)
TNF-α↓, GA Inhibits Tumor Necrosis Factor-a (TNF-a)
BID↑, GA Induces BID
BAD↑, GA Induces BAD
Cyt‑c↑, GA, induces the expression of cytochrome c in colorectal cancer HT-29, bladder cancer T24 and UMUC3, breast cancer MDA-MB-231, and human hepatocellular carcinoma cells
Casp3↑, GA Induces the Activation of Caspase-3 and Caspase-9
Casp9↑,
*AntiArt↑, GA inhibits RA by inhibiting the levels of cytokines and key inflammatory molecules [
*antiPs↑, recent study showed that GA could be used as an anti-psoriatic agent


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   BAD↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   IAP1↓, 1,   iNOS↓, 1,   MAPK↓, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   PI3K↓, 1,   Src↓, 1,   STAT3↓, 1,   STAT5↓, 1,  

Migration(tgid=13) ⓘ

FAK↓, 1,   MMP7↓, 1,   MMP9↓, 1,   MMPs↓, 1,   PKA↓, 1,   α-tubulin↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CXCR4↑, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiPs↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: CXCR4, Chemokine Receptor Type 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:79  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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