DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱

Source: HalifaxProj(prevent)

Type:

DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.

Scientific Papers found: Click to Expand⟱

4384-

,

Silver nanoparticles: synthesis, properties, and therapeutic applications

-

Review,

Var,

NA

AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,

5277-

3BP,

3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model

-

in-vivo,

PC,

Panc02

mouse model

HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,

5459-

AF,

Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells

-

in-vitro,

Ovarian,

NA

ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,

5460-

AF,

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

-

vitro+vivo,

Var,

4T1

RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,

5458-

AF,

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

-

in-vitro,

NSCLC,

NA

TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,

5468-

AF,

The gold complex auranofin: new perspectives for cancer therapy

-

Review,

Var,

NA

TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

-

Review,

Liver,

NA

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Nor,

L02

tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,

5978-

AgNPs,

Biological synthesis of silver nanoparticles and their medical applications

-

Review,

Var,

NA

Wound Healing↑, AntiCan↑, other↑, MPT↑, ROS↑, other↑, DNAdam↑,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

-

in-vitro,

GBM,

U251

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

GL26

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4401-

AgNPs,

Rad,

Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy

-

in-vitro,

BC,

NA

 Met NPs and AgNPs had average diameters of 51.5 ± 9.4 nm and 3.02 ± 0.03 nm,

RadioS↑, DNAdam↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

-

in-vitro,

BC,

MCF-7

-

in-vitro,

Nor,

MCF10

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

BT549

-

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,

4399-

AgNPs,

Chit,

Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells

-

in-vitro,

GBM,

U87MG

 2.4 μg mL(-1) for Ag NPs

DNAdam↑, ROS↑, MMP↓, eff↑,

4362-

AgNPs,

Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers

-

in-vitro,

CRC,

HCT116

18–45 nm.

-

in-vitro,

CRC,

HT29

-

in-vivo,

NA,

NA

Male Swiss nu/nu mice aged 5–8 weeks

eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,

4428-

AgNPs,

p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells

-

in-vitro,

AML,

Jurkat

toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

4371-

AgNPs,

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

-

in-vitro,

Liver,

HUH7

20−50 nm

eco-friendly approach silver nanoparticles (AgNPs) using root extracts of Beta vulgaris L.

ROS↑, selectivity↑, DNAdam↑, Apoptosis↑, GSH↓, lipid-P↑, MMP↓, DNAdam↑,

4564-

AgNPs,

GoldNP,

Cu,

Chemo,

PDT

Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review

-

Review,

Var,

NA

ROS↑, DNAdam↑, TumCCA↑, eff↑, Apoptosis↑, eff↓, ChemoSen↑,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

4549-

AgNPs,

Silver nanoparticles: Synthesis, medical applications and biosafety

-

Review,

Var,

NA

-

Review,

Diabetic,

NA

ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,

4542-

AgNPs,

Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update

-

Review,

NA,

NA

AntiCan↑, DNAdam↑, ATP↓, Apoptosis↑, ROS↓, TumCCA↑, *Bacteria↓, *BMD↑,

5144-

AgNPs,

Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice

-

in-vivo,

Nor,

NA

orally to 4 mg/kg of citrate-coated AgNPs over a period of 7 d.

wild type mice

*DNAdam↑, *toxicity↝, eff↝,

342-

AgNPs,

Silver nanoparticles; a new hope in cancer therapy?

-

Review,

NA,

NA

ROS↑, DNAdam↑, Apoptosis↑, mtDam↑,

334-

AgNPs,

Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53

-

in-vitro,

Colon,

HCT116

Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

-

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

322-

AgNPs,

Cisplatin,

Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin

-

in-vitro,

Ovarian,

A2780S

 25nm AgNPs capped with polyvinylpyrrolidone (PVP

 15ug/mL

 IC50: 7.9ug/mL : 3.1uM for combination treatment

-

in-vitro,

Ovarian,

SKOV3

-

in-vitro,

Ovarian,

OVCAR-3

 745ug/mL

 less sensitive to AgNPs

ROS↑, DNAdam↑, GSH/GSSG↓,

374-

AgNPs,

Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo

-

in-vitro,

BC,

MCF-7

-

in-vitro,

BC,

MDA-MB-231

-

in-vivo,

NA,

NA

 6, 9, or 12 mg total silver/kg

 mice

ER Stress↑, DNAdam↑, ROS↑, Apoptosis↑, GSH/GSSG↓, NADPH/NADP+↓, TumCG↓, UPR↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

362-

AgNPs,

Comparative and Mechanistic Study on the Anticancer Activity of Quinacrine-Based Silver and Gold Hybrid Nanoparticles in Head and Neck Cancer

-

vitro+vivo,

SCC,

SCC9

 0.5ug/mL

DNAdam↑, TumVol↓,

355-

AgNPs,

Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines

-

in-vitro,

Lung,

A549

 20–28 μg/ml

-

in-vitro,

NA,

BEAS-2B

 12–35 μg/ml

 normal cells

ROS↑, DNAdam↑, Apoptosis↑,

360-

AgNPs,

Moringa,

Cytotoxic and Genotoxic Evaluation of Biosynthesized Silver Nanoparticles Using Moringa oleifera on MCF-7 and HUVEC Cell Lines

-

in-vitro,

BC,

MCF-7

 5ug/mL

-

in-vitro,

BC,

HUVECs

 not significantly affected

DNAdam↑,

376-

AgNPs,

Antitumor activity of colloidal silver on MCF-7 human breast cancer cells

-

in-vitro,

BC,

MCF-7

 3.5 ng/mL

Apoptosis↑, LDH↓, SOD↑, DNAdam↑,

400-

AgNPs,

MF,

Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field

-

in-vitro,

Laryn,

HEp2

50mT/30mins

3.29 0.4 mol/mL

6x improvement when LEMF added (50mT/15mins)

TumCP↓, Casp3↑, P53↑, Beclin-1↑, TumAuto↑, GSR↑, ROS↑, MDA↑, ROS↑, SIRT1↑, Ca+2↑, Endon↑, DNAdam↑, Apoptosis↑, NF-kB↓,

386-

AgNPs,

Tam,

Synergistic anticancer effects and reduced genotoxicity of silver nanoparticles and tamoxifen in breast cancer cells

-

in-vitro,

BC,

MCF-7

35uM(AgNP)+20uM(Tam)

-

in-vitro,

BC,

MDA-MB-231

P53↑, BAX↑, Bcl-2↓, Casp3↑, DNAdam↑, TumCCA↑,

388-

AgNPs,

Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells

-

in-vitro,

BC,

MCF-7

 5 and 10 µg/mL

ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

2288-

AgNPs,

Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model

-

Review,

Var,

NA

*ROS↑, Akt↓, ERK↓, DNAdam↑, Ca+2↑, ROS↑, MMP↓, Cyt‑c↑, TumCCA↑, DNAdam↑, Apoptosis↑, P53↑, p‑ERK↑, ER Stress↑, cl‑ATF6↑, GRP78/BiP↑, CHOP↑, UPR↑,

5356-

AL,

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

-

Review,

GC,

NA

Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,

2646-

AL,

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress

-

in-vitro,

Pca,

DU145

-

in-vitro,

Melanoma,

RPMI-8226

AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

304-

ALA,

alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation

-

in-vitro,

Colon,

HT-29

 1 mM DHLA or 1 mM ALA.

mt-ROS↑, Apoptosis↑, Casp3↑, DNAdam↑, Bcl-xL↓, Dose↝,

1553-

Api,

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

-

Review,

NA,

NA

Dose∅, TumVol↓, Dose∅, COX2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,

1545-

Api,

The Potential Role of Apigenin in Cancer Prevention and Treatment

-

Review,

NA,

NA

TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,

1536-

Api,

Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells

-

in-vitro,

MM,

MSTO-211H

0, 10, 30, and 50 µM) of apigenin for 48 h and 72 h

-

in-vitro,

MM,

H2452

tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

313-

Api,

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

-

in-vitro,

Thyroid,

BCPAP

 25 uM

LC3s↝, p62↓, ROS↑, TumCCA↑, CDC25↓, TumAuto↑, Beclin-1↑, AVOs↑, DNAdam↑,

171-

Api,

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

-

Review,

Var,

NA

PI3K/Akt↓, NF-kB↓, CK2↓, FOXO↓, MAPK↝, ERK↓, p‑JAK↓, Wnt/(β-catenin)↓, ROS↑, CDC25↓, p‑STAT↓, DNAdam↑,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

-

Review,

Var,

NA

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

3396-

ART/DHA,

Progress on the study of the anticancer effects of artesunate

-

Review,

Var,

NA

TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,

Showing Research Papers: 1 to 50 of 262
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 262

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 2, GPx4↓, 2, GSH↓, 5, GSH∅, 1, GSH/GSSG↓, 2, GSR↑, 1, HO-2↑, 1, c-Iron↑, 1, lipid-P↑, 5, lipid-P↝, 1, MDA↑, 1, NADPH/NADP+↓, 1, NRF2↓, 1, NRF2↑, 1, ROS↓, 1, ROS↑, 38, mt-ROS↑, 1, SOD↑, 1, TrxR↓, 4,

Metal & Cofactor Biology ⓘ

Ferritin↓, 1, Tf↑, 1,

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1, AIF↑, 3, ATP↓, 6, CDC25↓, 3, ETC↓, 1, MMP↓, 13, MPT↑, 1, mtDam↑, 4, mt-OCR↓, 1, Raf↓, 1,

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1, AMPK↑, 1, cMyc↓, 1, GlucoseCon∅, 1, Glycolysis↓, 2, H2S↑, 1, HK2↓, 1, lactateProd↓, 1, lactateProd∅, 1, LDH↓, 3, NADPH↓, 1, PI3K/Akt↓, 1, p‑S6↓, 1, SIRT1↑, 3,

Cell Death ⓘ

Akt↓, 8, p‑Akt↓, 1, Apoptosis↑, 27, BAX↑, 13, Bax:Bcl2↑, 2, Bcl-2↓, 9, Bcl-2↑, 1, Bcl-xL↓, 2, BIM↑, 1, Casp↑, 5, Casp3↓, 1, Casp3↑, 17, Casp7↑, 1, Casp8↑, 6, Casp9↑, 9, CK2↓, 1, Cyt‑c↑, 8, Endon↑, 1, Fas↑, 3, Ferroptosis↑, 2, JNK↓, 1, JNK↑, 2, MAPK↓, 1, MAPK↑, 1, MAPK↝, 1, MDM2↓, 1, MLKL↑, 2, p‑MLKL↓, 1, Necroptosis↑, 2, p27↑, 1, p38↑, 2, survivin↓, 2, Telomerase↓, 1,

Transcription & Epigenetics ⓘ

other↑, 2, other↝, 3, PhotoS↑, 1, tumCV↓, 8,

Protein Folding & ER Stress ⓘ

cl‑ATF6↑, 1, CHOP↑, 1, ER Stress↓, 1, ER Stress↑, 5, GRP78/BiP↑, 2, HSP70/HSPA5↓, 1, UPR↑, 4,

Autophagy & Lysosomes ⓘ

AVOs↑, 1, Beclin-1↑, 2, LC3B↑, 1, LC3s↝, 1, p62↓, 1, p62↑, 1, TumAuto↑, 5, TumAuto↝, 1,

DNA Damage & Repair ⓘ

DNAdam↑, 51, P53↑, 8, P53↝, 1, p‑P53↑, 2, PARP↑, 1, p‑PARP↑, 1, cl‑PARP↑, 3, PCNA↓, 1, γH2AX↑, 1,

Cell Cycle & Senescence ⓘ

CDK1↓, 2, CDK1↑, 1, CDK2↓, 2, CDK2↑, 1, CDK4↓, 3, CDK4↑, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 2, CycB/CCNB1↑, 1, cycD1/CCND1↓, 4, cycE/CCNE↓, 3, E2Fs↓, 1, P21↑, 6, TumCCA↑, 17,

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, Diff↑, 1, EMT↓, 1, ERK↓, 4, p‑ERK↓, 1, p‑ERK↑, 1, FOXO↓, 1, GSK‐3β↓, 1, mTOR↓, 3, mTOR↑, 1, Nanog↓, 1, NOTCH1↓, 1, OCT4↓, 1, p‑P70S6K↓, 1, p‑P90RSK↑, 1, PI3K↓, 5, p‑STAT↓, 1, STAT3↓, 1, TOP2↓, 1, TumCG↓, 6, TumCG↑, 1, Wnt↓, 1, Wnt/(β-catenin)↓, 2,

Migration ⓘ

AP-1↓, 1, Ca+2↑, 4, Cdc42↑, 1, E-cadherin↑, 1, MMP2↓, 2, MMP7↓, 1, MMP9↓, 2, MMPs↓, 1, PKCδ↓, 1, RIP3↑, 1, p‑RIP3↑, 2, TGF-β↓, 2, TIMP2↑, 1, TumCI↓, 2, TumCMig↓, 2, TumCP↓, 8, TumMeta↓, 2, uPA↓, 1, Vim↓, 1, β-catenin/ZEB1↓, 2,

Angiogenesis & Vasculature ⓘ

angioG↓, 4, EPR↑, 3, HIF-1↓, 2, Hif1a↓, 4, VEGF↓, 3,

Barriers & Transport ⓘ

CellMemb↑, 1, P-gp↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 3, CXCR4↓, 1, IKKα↓, 1, IL12↑, 1, IL1α↓, 1, IL1β↓, 1, IL2↑, 1, IL6↓, 1, IL8↓, 1, Imm↑, 1, p‑JAK↓, 1, NF-kB↓, 6, NF-kB↑, 1, NF-kB↝, 1, PD-L1↓, 1, TNF-α↓, 1, TNF-α↑, 2,

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1, CDK6↑, 2,

Drug Metabolism & Resistance ⓘ

BioAv↓, 2, BioAv↑, 2, ChemoSen↑, 8, Dose↓, 1, Dose↝, 3, Dose∅, 3, eff↓, 11, eff↑, 25, eff↝, 4, Half-Life↓, 1, MDR1↓, 1, RadioS↑, 7, selectivity↓, 1, selectivity↑, 11,

Clinical Biomarkers ⓘ

Ferritin↓, 1, IL6↓, 1, LDH↓, 3, PD-L1↓, 1,

Functional Outcomes ⓘ

AntiCan↓, 1, AntiCan↑, 8, chemoP↑, 2, OS↑, 1, QoL↑, 1, toxicity↓, 2, toxicity↝, 1, TumVol↓, 3, TumW↓, 1, Wound Healing↑, 1,
Total Targets: 217

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

NRF2↑, 1, ROS↑, 2,

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,

DNA Damage & Repair ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

BMD↑, 1, GutMicro↑, 1,

Functional Outcomes ⓘ

AntiDiabetic↑, 1, Bone Healing↑, 1, chemoP↑, 1, toxicity↓, 1, toxicity↝, 2, Wound Healing↑, 1,

Infection & Microbiome ⓘ

AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 2,
Total Targets: 23

Scientific Paper Hit Count for: DNAdam, DNA damage

30 Silver-NanoParticles
14 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
10 Curcumin
8 Fisetin
7 Radiotherapy/Radiation
7 salinomycin
6 Artemisinin
6 Cisplatin
6 Apigenin (mainly Parsley)
6 Ashwagandha(Withaferin A)
6 Carvacrol
6 Piperlongumine
6 Quercetin
5 Copper and Cu NanoParticles
5 Berberine
5 Betulinic acid
5 Chrysin
5 diet FMD Fasting Mimicking Diet
5 Sulforaphane (mainly Broccoli)
4 Auranofin
4 Chemotherapy
4 Allicin (mainly Garlic)
4 Baicalein
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Ellagic acid
4 Emodin
4 Electrical Pulses
4 Selenium NanoParticles
4 Shikonin
4 Thymoquinone
3 borneol
3 Rosmarinic acid
3 Lycopene
3 Magnolol
3 Magnetic Field Rotating
3 Propolis -bee glue
3 Phenethyl isothiocyanate
3 Resveratrol
2 chitosan
2 Metformin
2 doxorubicin
2 Melatonin
2 Boswellia (frankincense)
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Cat’s Claw
2 diet Short Term Fasting
2 Disulfiram
2 EGCG (Epigallocatechin Gallate)
2 Gallic acid
2 Garcinol
2 Hydroxycinnamic-acid
2 Juglone
2 Propyl gallate
2 Selenite (Sodium)
2 Ursolic acid
2 VitK3,menadione
2 Vitamin K2
1 3-bromopyruvate
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 Moringa oleifera
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Boron
1 Black phosphorus
1 Zinc
1 carboplatin
1 Catechins
1 Chlorogenic acid
1 Chlorophyllin
1 chemodynamic therapy
1 Deguelin
1 immunotherapy
1 Butyrate
1 Ferulic acid
1 Galloflavin
1 Gambogic Acid
1 γ-linolenic acid (Borage Oil)
1 Honokiol
1 HydroxyTyrosol
1 Luteolin
1 Nimbolide
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Aflavin-3,3′-digallate
1 temozolomide
1 Iron
1 Magnesium
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Home Page