AFP Cancer Research Results

AFP, α-fetal protein: Click to Expand ⟱
Source:
Type: biomarker
α-fetal protein (AFP) is a protein that is typically produced by the liver and yolk sac of a developing fetus. In adults, high levels of AFP in the blood can be a sign of certain types of cancer, particularly those of the liver, testes, and ovaries.

-AFP is primarily known as a serum biomarker in hepatocellular carcinoma (HCC), but its expression and prognostic significance can also extend to other malignancies.


Scientific Papers found: Click to Expand⟱
5892- CAR,  SRF,    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study
- in-vivo, HCC, NA
Hif1a↓, CVR showed an HIF-1α inhibitory potential, which is highly expressed in HCC tissues.
AFP↑, CVR/SOR enhanced liver functions and decreased AFP level.
hepatoP↑, CVR improves liver functions and enhances SOR anti-cancer activity
STAT3↓, CVR/SOR hindered HCC progression by downregulating STAT3, JAK2, and FGL1.
JAK2↓,
*CD8+↑, CVR/SOR induced tumor immunity via increasing CD8+ T cells.
ChemoSen↑, CVR/SOR is a powerful combination for tumor repression and enhancing SOR efficiency in HCC by modulating FGL1
Dose↝, 10 mg/kg SOR by intragastic tube for 6 weeks daily;
angioG↓, CVR improves SOR attenuation efficacy against TAA-induced angiogenesis


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

AFP↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: AFP, α-fetal protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:829  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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