TBARS Cancer Research Results

TBARS, Thiobarbituric Acid Reactive Substances: Click to Expand ⟱
Source:
Type: measure
TBARS (Thiobarbituric Acid Reactive Substances) is a measure of lipid peroxidation, which is the oxidative degradation of lipids. Lipid peroxidation is a process in which free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs), leading to cell damage.

Research has shown that TBARS levels are often elevated in cancer patients. This is because cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, which can lead to increased lipid peroxidation.
Scientific Papers found: Click to Expand⟱
727- Bor,  RSL3,  erastin,    Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy
- in-vitro, Liver, HepG2
ROS↑, at high, pharmacological concentrations
GSH↓, BA can increase intracellular ROS,
TBARS↑,
Ferroptosis↑,
ChemoSen↑, These observations suggest that BA could be exploited as a chemo-sensitizer agent in order to overcome cancer drug resistance in selected conditions.

6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, D-Carvone treatment suppressed the viability of Molt-4 cells and the IC50 was determined at 20 µM/ml.
ROS↑, The D-Carvone treatment was increased the oxidative stress and reduced the level of antioxidants in the Molt-4 cell lines.
antiOx↓,
MMP↓, diminished MMP was noted in the D-Carvone treatment.
Apoptosis↑, induced the apoptosis in a time and dose dependent manner by the activation of caspases-8, -9 and -3.
Casp8↑,
Casp9↑,
Casp3↑,
*neuroP↑, D-carvone also possessed the neuroprotective [18], anticancer [19,20], antiarthritis [21], and anti-ulcerative colitis [22] activities.
AntiCan↑,
*AntiArt↑,
TBARS↑, We found an augmented level of TBARS and decreased status of SOD, GSH and CAT enzymes in the D-carvone (15 and 20 µM/ml) treated Molt-4 cells when compared to control cells.
SOD↓,
GSH↓,
Catalase↓,

1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, Treatment of HepG2 cells with EA and gamma radiation showed increased reactive oxygen species generation
P53↑, up regulation of p53 protein expression
TumCCA↑, combination treatment increased G2/M phase cell population
IL6↓, decreased IL-6, COX–2 and TNF-α expression
COX2↓,
TNF-α↓,
MMP↓, caused a loss in mitochondrial membrane potential
angioG↓, decreased level of angiogenesis marker MMP-9
MMP9↓,
BAX↑,
Casp3↑,
Apoptosis↑,
RadioS↑,
TBARS↑, EA increased TBARS level in HepG2 cells after irradiation
GSH↓, EA decreased the reduced glutathione content in HepG2 cells after irradiation
Bax:Bcl2↑, Combination treatment increased the Bax/Bcl2 ratio
p‑NF-kB↓, EA along with radiation decreased p-NF-κB level in tumour cells
p‑STAT3↓, Radiation and EA combination treatment decreased p-STAT3 level in tumour cells

6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, geraniol decreased C666-1 cell viability
MMP↓, The geraniol treatment reduced MMP and promoted apoptosis in C666-1 cells
Apoptosis↑,
TBARS↑, levels of TBARS were increased, while decreased GSH and SOD levels were observed in the geraniol-treated C666-1 cells.
GSH↓,
SOD↓,
BAX↑, geraniol also promoted pro-apoptotic gene expressions, including Bax, caspase-3, and -9, and additionally inhibited PI3K/Akt/mTOR signaling in the C666-1 cells.
Casp3↑,
Casp9↑,
PI3K↓,
Akt↓,
mTOR↓,
DNAdam↑, it was clear that geraniol could increase nuclear damage and facilitate apoptosis in C666-1 cells
ROS↑, geraniol efficiently reduces antioxidants while improving oxidative stress in C666-1 cells

3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, Simultaneous supplementation with black pepper or piperine lowered TBARS and CD levels and maintained SOD, CAT, GPx, GST, and GSH levels to near those of control rats.
*SOD↑,
*Catalase↑,
*GSTs↑,
*GPx↑,
*GSH↑,
*ROS↓, can reduce high-fat diet induced oxidative stress to the cells.


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GSH↓, 4,   ROS↑, 4,   SOD↓, 2,   TBARS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 2,   Bax:Bcl2↑, 1,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 2,   Ferroptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL6↓, 1,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   ROS↓, 1,   SOD↑, 1,   TBARS↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: TBARS, Thiobarbituric Acid Reactive Substances
1 Boron
1 Ras-selective lethal 3
1 erastin
1 Carvone
1 Ellagic acid
1 Radiotherapy/Radiation
1 Geraniol
1 Piperine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:862  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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