miR-127-5p Cancer Research Results

miR-127-5p, miR-127-5p: Click to Expand ⟱

Source:

Type: microRNA

miR-127-5p has been found to be downregulated in cancer tissues and cell lines, and its overexpression has been shown to inhibit cancer cell proliferation and induce apoptosis.

Scientific Papers found: Click to Expand⟱

756-

Bor,

Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

in-vitro,

BC,

MCF-7

45.69 mM

However, it cannot be said that it improves the metastasis properties of breast cancer stem cells.

COL1A1↓,
Vim↓,
miR-127-5p↑,
Zeb1↑, expression of the miR-127-5p, ZEB1, CDH1, ITGB1 , ITGA5 , LAMA5 , and SNAIL, was up-regulated in dose-treated BC-SCs
CDH1↑,
ITGB1↑,
ITGA5↑,
LAMA5↑,
Snail↑,

736-

Bor,

Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

in-vitro,

BC,

MCF-7

45.69 mM

miR-126↑, boric acid could induce miR-127-5p expression
COL1A1↓,
Vim↓,
Zeb1↑, expression of the miR-127-5p, ZEB1, CDH1, ITGB1, ITGA5, LAMA5, and SNAIL, was up-regulated in dose-treated BC-SCs
CDH1↑,
ITGB1↑,
ITGA5↑,
LAMA5↑,
Snail↑,
miR-127-5p↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

miR-127-5p↑, 2,

Migration ⓘ

CDH1↑, 2, COL1A1↓, 2, ITGA5↑, 2, ITGB1↑, 2, LAMA5↑, 2, Snail↑, 2, Vim↓, 2, Zeb1↑, 2,

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-127-5p, miR-127-5p

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells