Rac1 Cancer Research Results

Rac1, Ras-related C3 botulinum toxin substrate 1: Click to Expand ⟱

Source:

Type:

Rac1 is a small GTPase that plays a crucial role in various cellular processes, including cell growth, migration, and survival.
Rac1 is involved in the regulation of cell migration and invasion, which are critical steps in the metastasis of cancer cells.
Rac1 has been found to be overexpressed in cancer tissues and cell lines, and its expression has been associated with poor prognosis.
Where Low Rac1 expression is found it has been associated with good prognosis and improved overall survival.

Scientific Papers found: Click to Expand⟱

3267-

Lyco,

Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways

in-vitro,

Nor,

HUVECs

*VEGF↓, highest dose used (400 μg/plug) completely inhibited the formation of vascular endothelial cells induced by vascular endothelial growth factor (VEGF).
*MMP2↓, lycopene inhibited tube formation, invasion, and migration in HUVECs, and such actions were accompanied by reduced activities of matrix metalloproteinase-2, urokinase-type plasminogen activator, and protein expression of Rac1
*uPA↓,
*Rac1↑,
*TIMP2↑, and by enhancing protein expression of tissue inhibitors of metalloproteinase-2 and plasminogen activator inhibitor-1.
*p38↓, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.
*Akt↓,
*angioG↓, anti-angiogenic effect of lycopene both in vitro and in vivo.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death ⓘ

Akt↓, 1, p38↓, 1,

Migration ⓘ

MMP2↓, 1, Rac1↑, 1, TIMP2↑, 1, uPA↓, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, VEGF↓, 1,
Total Targets: 8

Scientific Paper Hit Count for: Rac1, Ras-related C3 botulinum toxin substrate 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells