ZEB2 Cancer Research Results

ZEB2, Zinc Finger E-Box Binding Homeobox 2: Click to Expand ⟱
Source:
Type:
SIP1 (Smad Interacting Protein 1, also known as ZEB2).
ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a transcription factor that plays a crucial role in the regulation of gene expression, particularly in the context of epithelial-to-mesenchymal transition (EMT) and cancer progression.
ZEB2 has been found to be overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer.
Scientific Papers found: Click to Expand⟱
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, Linoleic acid (LA) induces proliferation and invasion in breast cancer cells.
E-cadherin↓,
Snail↑, increase of Snail1, Snail2, Twist1, Twist2 and Sip1 expressions.
Twist↑,
ZEB2↑,
FAK↑,
NF-kB↑,
MMP2↓, Furthermore, LA induces FAK and NFκB activation, MMP-2 and -9 secretions, migration and invasion.
MMP9↓,
*EMT↑, LA promotes an EMT-like process in MCF10A
TumCI↑,

800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, reverses epithelial-to-mesenchymal transition (EMT), that is, it induces mesenchymal-to-epithelial transition (MET)
MET↑,
E-cadherin↑,
Vim↓,
Zeb1↓,
ZEB2↑,
miR-200c↑, miR-200
Let-7↑,
p‑β-catenin/ZEB1↓, garcinol was found to inhibit NF-κB, miRNAs, vimentin, and nuclear β-catenin
NF-kB↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Let-7↑, 1,  

Migration ⓘ

E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↑, 1,   MET↑, 1,   miR-200c↑, 1,   MMP2↓, 1,   MMP9↓, 1,   Snail↑, 1,   TumCI↑, 1,   TumCP↑, 1,   Twist↑, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↑, 2,   p‑β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   NF-kB↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ZEB2, Zinc Finger E-Box Binding Homeobox 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:892  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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