AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
276- ALA,    Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B
P53↑, EMT↓, AMPK↑, cycD1/CCND1↓, TumCMig↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, Var, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2/PTGS2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
1076- ART/DHA,    The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
- Review, Var, NA
Ferroptosis↑, ROS↑, ER Stress↑, i-Iron↓, TumAuto↑, AMPK↑, mTOR↑, P70S6K↑, Fenton↑, lipid-P↑, ROS↑, ChemoSen↑, NRF2↑, NRF2↓,
5135- ART/DHA,    Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells
- vitro+vivo, Var, NA
mTORC1↓, AMPK↑, TumCG↓,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, Synergy↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
1524- Ba,    AMPK_in_Human_Lung_Carcinoma_A549_Cells">Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2389- BA,    Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor
- in-vitro, Obesity, 3T3
*ECAR↑, *OCR↓, *p‑AMPK↑, *p‑ACC↑, *Glycolysis↑, *lipidDe↓, *SREBP1/SREBF1↓, *FAO↑, *HK2↑, *PKM2↑, *LDHA↑, *PDKs↓, *ACC↓,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
1395- BBR,    Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation
- in-vitro, GC, NA
Apoptosis↑, ROS↑, MMP↓, ATP↓, AMPK↑, TP53↑, p‑MAPK↓, p‑ERK↓,
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2714- BBR,    Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
- Review, Var, NA
AMPK↑, ITGB1↓,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, Synergy↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, Synergy↑, Synergy↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
5509- bemA,    Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
- Review, Nor, NA
LDL↓, AMPK↑, ACLY↓,
5513- bemA,    ACLY inhibition promotes tumour immunity and suppresses liver cancer
- in-vitro, Liver, NA
ACLY↓, AMPK↑, eff↑, other↝, eff↝,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, Synergy↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP/DDIT3↑, *toxicity↓,
2730- BetA,    Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
699- Bor,    Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *TNF-α↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *Sema3A/PlexinA1↑,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, Var, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2/PTGS2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,

Showing Research Papers: 1 to 50 of 226
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 226

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 4,   GSH↓, 5,   GSH↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 5,   i-Iron↓, 1,   lipid-P↑, 8,   MDA↑, 5,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 9,   Prx↓, 1,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 7,   ROS↑, 71,   ROS⇅, 3,   mt-ROS↑, 8,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   TKT↝, 1,   Trx↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 3,   compI↓, 3,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam↑, 8,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 3,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↓, 5,   ACC↑, 5,   p‑ACC↑, 2,   p‑ACC-α↑, 1,   ACLY↓, 5,   adiP↑, 1,   AMP↑, 2,   AMPK↓, 1,   AMPK↑, 128,   p‑AMPK↑, 20,   ATP↓, 17,   mt-ATP↓, 1,   CRM↑, 2,   ECAR↓, 3,   FAO↑, 1,   FASN↓, 9,   FDG↓, 1,   G6PD↓, 3,   GLS↓, 3,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 22,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 15,   HK2↑, 1,   lactateProd↓, 7,   lactateProd↑, 3,   LDHA↓, 6,   LDHA↑, 1,   LDL↓, 1,   lipidLev↓, 2,   lipoGen↓, 2,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PFK1↓, 1,   PKM2↓, 11,   PKM2↑, 1,   PPP↓, 2,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 5,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↑, 55,   BAD↓, 1,   BAD↑, 3,   Bak↑, 4,   BAX↓, 2,   BAX↑, 26,   Bax:Bcl2↑, 7,   Bcl-2↓, 33,   Bcl-xL↓, 9,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 9,   Casp3↓, 1,   Casp3↑, 34,   cl‑Casp3↑, 10,   Casp7↑, 4,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 21,   cl‑Casp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 22,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 8,   FADD↑, 5,   Fas↓, 1,   Fas↑, 9,   FasL↑, 6,   Ferroptosis↑, 9,   IAP1↓, 1,   iNOS↓, 4,   Mcl-1↓, 6,   Mcl-1↑, 1,   MDM2↓, 2,   MOMP↑, 1,   NAIP↓, 1,   p38↓, 1,   p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 10,   TRAIL↑, 2,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 42,   Akt↑, 4,   p‑Akt↓, 10,   p‑Akt↑, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   cMET↓, 2,   EF-1α↓, 1,   EGFR↓, 11,   ERK↓, 11,   ERK↑, 3,   p‑ERK↓, 2,   IGF-1R↓, 1,   IKKα↓, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 10,   MAPK↓, 9,   MAPK↑, 4,   p‑MAPK↓, 1,   MEK↓, 1,   mTOR↓, 56,   mTOR↑, 10,   mTOR∅, 1,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 5,   P70S6K↑, 1,   P90RSK↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 27,   PI3K↑, 4,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PP2A↑, 1,   PTEN↑, 5,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   p‑S6K↓, 4,   Sp1/3/4↓, 3,   Src↓, 1,   STAT↓, 3,   STAT3↓, 21,   STAT3↑, 1,   p‑STAT3↓, 5,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 4,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 12,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   H3↑, 1,   p‑H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 4,   HDAC∅, 1,   HDAC1↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 3,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   miR-326-5p↑, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-592↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↓, 3,   other↑, 1,   other↝, 3,   SOX2↓, 3,   SOX4↓, 2,   TCF-4↓, 1,   tumCV↓, 23,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 15,   Erlin1↑, 1,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 4,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 10,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 6,   PARK2↑, 2,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 27,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↑, 21,   DNArepair↓, 1,   NBR2↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 29,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 19,   cl‑PARP1↑, 1,   PCNA↓, 5,   Telomerase↓, 1,   TOP1↓, 2,   TOP2↓, 3,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 2,   CDK2↓, 8,   CDK2↑, 2,   CDK4↓, 13,   CDK4↑, 2,   CDK6↓, 5,   CDK6↑, 2,   CDK7↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 20,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 6,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 13,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 47,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMI1↓, 2,   BMP7/OP1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 2,   cFos↓, 5,   CSCs?, 1,   CSCs↓, 14,   Diff↓, 1,   Diff↑, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGFBP1↑, 2,   Ki-67↓, 6,   Let-7↑, 2,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH1↓, 2,   NOTCH3↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 3,   Smo↓, 1,   Sufu↓, 1,   TumCG↓, 30,   TumCG↑, 1,   TumCP↓, 46,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 16,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 4,   ASAP2↓, 1,   Ca+2↑, 7,   CAFs/TAFs↝, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 17,   EMT↓, 24,   EMT↑, 1,   EMT↝, 1,   F-actin↑, 1,   FAK↓, 3,   Fibronectin↓, 1,   Furin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 21,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 24,   MMPs↓, 6,   N-cadherin↓, 10,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 3,   p‑SMAD2↓, 1,   Snail↓, 7,   talin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP2↓, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 29,   TumCMig↓, 23,   TumMeta↓, 19,   Twist↓, 5,   TXNIP↓, 1,   uPA↓, 6,   Vim↓, 14,   Zeb1↓, 4,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   angioG↑, 1,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   Hypoxia↓, 1,   LOX1↓, 1,   NO↑, 4,   PHDs↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 24,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 7,   GLUT1↑, 2,   GLUT2↓, 1,   GLUT3↓, 1,   MMP↓, 39,   MPT↑, 2,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 27,   CXCL1↓, 1,   CXCR4↓, 4,   DCells↑, 1,   DR4↑, 2,   DR4∅, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IL1↓, 4,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 11,   IL8↓, 3,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 7,   LRIG1↑, 1,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   NF-kB↓, 38,   NF-kB↑, 2,   p‑NF-kB↓, 2,   NK cell↑, 1,   p50↓, 1,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PGE2↓, 8,   PSA↓, 2,   TCF↓, 2,   TNF-α↓, 8,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 10,   BioAv↑, 4,   BioAv↝, 4,   ChemoSen↑, 43,   ChemoSen⇅, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 3,   Dose↝, 13,   Dose∅, 4,   eff↓, 21,   eff↑, 23,   eff↝, 5,   Half-Life↓, 3,   Half-Life↝, 5,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P450↓, 1,   RadioS↑, 20,   selectivity↑, 17,   Synergy↑, 27,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BMD↑, 1,   EGFR↓, 11,   Ferritin↓, 1,   FOXM1↓, 2,   IL6↓, 11,   KRAS↓, 1,   LDH↓, 5,   p‑LDH↓, 1,   Myc↓, 3,   PD-L1↓, 6,   PSA↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 10,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 7,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 6,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 7,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   PFS∅, 1,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 7,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 3,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 623

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 39,   mt-antiOx↑, 1,   Catalase↑, 13,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 8,   GPx4↑, 2,   GSH↑, 21,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2∅, 1,   HO-1↑, 20,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 18,   mt-lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 14,   MPO↓, 3,   NQO1↑, 5,   NRF2↑, 35,   RNS↓, 1,   ROS↓, 63,   ROS↑, 1,   SOD↑, 19,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TOS↓, 1,   Trx1↑, 1,   TrxR1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 4,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 2,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 6,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   ACC↑, 1,   p‑ACC↑, 1,   Acetyl-CoA↓, 2,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 12,   AMPK↑, 76,   p‑AMPK↑, 8,   ATP↑, 7,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 4,   ECAR↓, 1,   ECAR↑, 1,   FAO↑, 3,   FASN↓, 1,   G6PD↑, 1,   glucoNG↓, 1,   glucose↓, 9,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 6,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   lipoGen↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PDKs↓, 1,   PGM1?, 1,   PKM2↓, 2,   PKM2↑, 1,   SIRT1↑, 27,   SIRT1↝, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 5,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 8,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 3,   cl‑Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 4,   iNOS↓, 7,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 8,   p‑Akt↓, 1,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 2,   ERK↑, 4,   p‑ERK↓, 1,   p‑ERK↑, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 6,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 10,   MAPK↑, 2,   mTOR↓, 12,   mTOR↑, 2,   p‑mTOR↓, 2,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 4,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 2,   PP2A↑, 3,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 1,   p‑cMyc↑, 1,   FOXO↑, 2,   FOXO1↝, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 3,   ER Stress↓, 4,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 2,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 4,   p62↑, 1,   PARK2↑, 4,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 2,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   MMP3↓, 1,   MMP9↓, 6,   PDGF↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 2,   TGF-β↑, 2,   TGF-β1↓, 1,   TXNIP↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 3,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 3,   NO↓, 5,   VCAM-1↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 10,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 10,   TRPC1↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 12,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 15,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 18,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 56,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 4,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 19,   TNF-α↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 1,   AChE↓, 8,   ADAM10↑, 1,   BChE↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 15,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 12,   BioAv↝, 11,   BioEnh↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   eff↓, 1,   eff↑, 8,   eff↝, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 2,   AST↓, 10,   BG↓, 1,   BloodF↑, 1,   BMD↑, 4,   BP↓, 5,   BP↝, 1,   BP∅, 1,   CRP↓, 3,   IL6↓, 18,   IRes↑, 1,   IRes↝, 1,   LDH↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 11,   antiAll↑, 5,   AntiCan↑, 4,   antiCG↑, 1,   AntiDiabetic↑, 8,   AntiTum↑, 2,   cardioP↑, 17,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 21,   diuretic↑, 1,   hepatoP↑, 22,   memory↑, 19,   motorD↑, 5,   neuroP↑, 42,   NP/CIPN↓, 1,   Obesity↓, 8,   OS↑, 4,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 3,   toxicity↓, 12,   toxicity⇅, 1,   toxicity↝, 3,   toxicity∅, 2,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 11,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 381

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
17 Resveratrol
14 Metformin
10 Berberine
10 Capsaicin
8 Fisetin
7 Alpha-Lipoic-Acid
7 Curcumin
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Hydrogen Gas
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Betulinic acid
4 Caffeic acid
4 diet Short Term Fasting
4 lambertianic acid
4 Quercetin
4 Urolithin
3 Aspirin
3 Ashwagandha(Withaferin A)
3 Chrysin
3 Calorie Restriction Mimetics
3 diet FMD Fasting Mimicking Diet
3 Honokiol
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnolol
3 Magnetic Field Rotating
3 Morin
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Baicalin
2 bempedoic acid
2 Boron
2 Chlorogenic acid
2 HydroxyCitric Acid
2 Emodin
2 Gambogic Acid
2 Inositol
2 isoorientin
2 Juglone
2 Luteolin
2 Methylene blue
2 Methyl salicylate / Sweet Birch oil
2 Magnetic Fields
2 Shikonin
2 Thymoquinone
2 Vitamin K2
2 Vitexin
1 Astragalus
1 Andrographis
1 Radiotherapy/Radiation
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Chemotherapy
1 Boswellia (frankincense)
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Celastrol
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Spermidine
1 Garcinol
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dandelion Root
1 Ellagic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Hibiscus sabdariffa
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 Licochalcone A
1 Licorice
1 Lycopene
1 Matrine
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Piperine
1 Pterostilbene
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Gallic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:9  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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