Neut Cancer Research Results

Neut, neutrophils: Click to Expand ⟱
Source:
Type: white blood cell
Neutrophils are a type of white blood cell that plays a crucial role in the immune system. They are involved in the defense against infections and inflammation.
High levels of neutrophils in the tumor microenvironment have been linked to poor prognosis in various types of cancer, including breast, lung, and colon cancer.

Neutropenia is an abnormally low number of circulating neutrophils
Scientific Papers found: Click to Expand⟱
6802- EA,    Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate
- Human, Pca, NA
*toxicity↓, A reduction in systemic toxicity, statistically significant for neutropenia, associated with better results in term of OR rate, ICR, and BR were observed in group B compared with group A.
chemoP↑, ellagic acid as support therapy reduces chemotherapy induced toxicity, in particular neutropenia, in HRCP patients
Neut↑,
PSA↓, In group B, serum PSA concentrations markedly declined (>75%)
Dose↝, After reviewing the literature, a daily dose of 180 mg (60 g/every 8 h) active principle was selected and administered orally before meals with water (200–250 ml) throughout the chemotherapy cycles and during the period between cycles.

6634- Ech,    Echinacea purpurea: Pharmacology, phytochemistry and analysis methods
- Review, Var, NA
AntiArt↑, this species has been traditionally employed for the treatment of toothache, bowel pain, snake bite, skin disorders, seizure, chronic arthritis, and cancer
*Imm↑, The immunostimulant activity of the plant or its preparations is caused by three mechanisms:
*Neut↑, activation of the neutrophils, macrophages, polymorphonuclear leukocytes (PMN), and natural killer (NK) cells.[
*NK cell↑,
*COX1↓, This effect may be attributed to the inhibition of COX‑1 and to a lesser extent COX‑2 by alkamides.
*COX2↓,
*Inflam↓, The Echinacea preparation, interestingly, has reversed the inflammation caused by some bacteria in a culture of epithelial cells by reducing cytokines
TumCG↑, The extract of the flowers and cichoric acid inhibited both the human colon cancer cell lines Caco‑2 and HCT‑116 in a dose dependent manner after 48 h.
*toxicity↓, Generally, animal studies of various preparations of Echinacea species have shown low toxicity.

2051- PB,    Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium
- in-vivo, Inf, NA
*Inf↓, PBA has a previously undiscovered protective role in host mucosal defense during infection
*GutMicro↑, PBA to Taconic mice resulted in the increase of intestinal Lactobacillales and segmented filamentous bacteria (SFB)
*IL17↑, increase of interleukin 17 (IL-17) production by intestinal cells
*Inflam↓, lower levels of inflammation
*ER Stress↓, PBA also plays a role in the reduction of endoplasmic reticulum (ER) stress caused by the unfolded protein response (UPR), thereby suppressing oxidative stress in several animal models
*ROS↓,
*OS↑, PBA was shown to increase the life span of flies, which was associated with both a global increase in histone acetylation and a marked alteration of gene expression
*Bacteria↓, PBA administration was shown to inhibit the growth of Helicobacter pylori and Escherichia coli
*Neut↑, these results indicated that PBA treatment reduces intestinal inflammation, the recruitment of neutrophils to the gut
*toxicity↓, PBA, which has been safely used in children and adults for the past 20 years to treat urea cycle disorders


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Neut↑, 1,   PSA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 1,   IL17↑, 1,   Imm↑, 1,   Inflam↓, 2,   Neut↑, 2,   NK cell↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Inf↓, 1,  
Total Targets: 14

Scientific Paper Hit Count for: Neut, neutrophils
1 Ellagic acid
1 Echinacea
1 Phenylbutyrate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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