Neut Cancer Research Results

Neut, neutrophils: Click to Expand ⟱
Source:
Type: white blood cell
Neutrophils are a type of white blood cell that plays a crucial role in the immune system. They are involved in the defense against infections and inflammation.
High levels of neutrophils in the tumor microenvironment have been linked to poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
2051- PB,    Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium
- in-vivo, Inf, NA
*Inf↓, PBA has a previously undiscovered protective role in host mucosal defense during infection
*GutMicro↑, PBA to Taconic mice resulted in the increase of intestinal Lactobacillales and segmented filamentous bacteria (SFB)
*IL17↑, increase of interleukin 17 (IL-17) production by intestinal cells
*Inflam↓, lower levels of inflammation
*ER Stress↓, PBA also plays a role in the reduction of endoplasmic reticulum (ER) stress caused by the unfolded protein response (UPR), thereby suppressing oxidative stress in several animal models
*ROS↓,
*OS↑, PBA was shown to increase the life span of flies, which was associated with both a global increase in histone acetylation and a marked alteration of gene expression
*Bacteria↓, PBA administration was shown to inhibit the growth of Helicobacter pylori and Escherichia coli
*Neut↑, these results indicated that PBA treatment reduces intestinal inflammation, the recruitment of neutrophils to the gut
*toxicity↓, PBA, which has been safely used in children and adults for the past 20 years to treat urea cycle disorders


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL17↑, 1,   Inflam↓, 1,   Neut↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Inf↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: Neut, neutrophils
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:910  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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