TAMS Cancer Research Results

TAMS, tumor-associated macrophages: Click to Expand ⟱
Source:
Type:
Tumor-Associated Macrophages (TAMs)
TAMs are a type of immune cell found abundantly within the tumor microenvironment. They originate from circulating monocytes that differentiate into macrophages upon migrating into tissues.
TAMs produce various growth factors, such as epidermal growth factor (EGF) and transforming growth factor-beta (TGF-β), which can directly stimulate tumor cell proliferation and survival.
By secreting vascular endothelial growth factor (VEGF) and other pro-angiogenic factors, TAMs facilitate the formation of new blood vessels, ensuring that tumors receive an adequate supply of oxygen and nutrients.

High densities of TAMs are found in many tumor types, including breast, lung, colorectal, and pancreatic cancers, among others.
high infiltration of TAMs in tumors is correlated with worse overall survival, aggressive disease, increased metastatic potential, and resistance to therapy.
Scientific Papers found: Click to Expand⟱
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, identified sodium bicarbonate (NaBi) as the potent metabolic reprogramming agent that enhanced antitumor responses in the acidic TME.
eff↑, NaBi and oAd-αCD47 therapy significantly inhibited tumor growth and produced complete immune control in various tumor-bearing mouse models.
TumMeta↓, suggesting its potential as an effective neoadjuvant treatment for preventing postoperative tumor recurrence and metastasis.
pH↑, NaBi improves the acidity of the TME and activates the CaMKII/CREB/PGC1α mitochondrial biosynthesis signaling pathway
CaMKII ↑,
CREB↑,
PGC-1α↑, NaBi increases the mitochondrial content of T cells and BMDMs by promoting the expression of PGC1α mediated by the Ca2+-CaMKII-CREB signaling pathway in an LA environment
AntiTum↑, oral NaBi enhances the antitumor effect of oAd-αCD47.
Imm↑, We proposed that sodium bicarbonate (NaBi) can act as an immunomodulator to reprogram metabolic disorders of CD8+ T cells and TAMs in an acidic environment.
CD8+↑, Combination therapy remodels the immunosuppressive microenvironment to promote activation of CD8+ T cells and TAMs
TAMS↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↑, 1,  

Migration ⓘ

TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

TAMS↑, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Functional Outcomes ⓘ

AntiTum↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TAMS, tumor-associated macrophages
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:912  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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