ASK1 Cancer Research Results
ASK1, Apoptosis Signal-regulating Kinase 1: Click to Expand ⟱
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ASK1 (Apoptosis Signal-regulating Kinase 1) is a protein kinase that plays a crucial role in cell signaling pathways, particularly in the regulation of apoptosis (programmed cell death) and cell survival.
ASK1 if often overexpressed and has been linked to tumor progression and poor prognosis.
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Scientific Papers found: Click to Expand⟱
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
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in-vitro, |
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SUM159 |
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in-vitro, |
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4T1 |
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PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,
Showing Research Papers: 1 to 4 of 4
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
GSH↓, 1, hyperG↓, 1, p‑NRF2↓, 1, ROS↑, 3, i-ROS↑, 1, TrxR↓, 1,
Metal & Cofactor Biology ⓘ
KLF5↓, 1,
Mitochondria & Bioenergetics ⓘ
MMP↓, 2, XIAP↓, 1,
Core Metabolism/Glycolysis ⓘ
cMyc↓, 1, Glycolysis↓, 1, HK2↓, 1, LDHA↓, 1, PDK1↓, 1, PPARγ↓, 1,
Cell Death ⓘ
Akt↓, 1, Akt↑, 2, p‑Akt↓, 1, Apoptosis↑, 1, ASK1↑, 4, BAX↑, 2, Bcl-2↓, 2, BIM↑, 1, Casp3↑, 4, Casp8↑, 1, Casp9↑, 2, cFLIP↓, 1, Cyt‑c↑, 1, Cyt‑c↝, 1, DR5↑, 1, JNK↑, 1, p38↑, 1, p‑p38↑, 1, survivin↓, 1, Telomerase↓, 1, TRAIL↑, 1,
Kinase & Signal Transduction ⓘ
AMPKα↑, 1,
Transcription & Epigenetics ⓘ
other?, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, ER Stress↓, 1, GRP78/BiP↓, 1, HSP27↑, 1,
DNA Damage & Repair ⓘ
DNArepair↓, 1,
Cell Cycle & Senescence ⓘ
CDK1↓, 1, CDK4↑, 2, P21↑, 1, TumCCA↑, 2,
Proliferation, Differentiation & Cell State ⓘ
ERK↑, 1, Gli1↓, 1, p‑GSK‐3β↑, 1, HDAC↓, 1, IGFBP3↑, 1, mTOR↑, 2, p‑mTOR↓, 1, Nanog↓, 1, NOTCH↓, 1, OCT4↓, 2, PI3K↑, 2, PTEN↑, 1, Shh↓, 1, Smo↓, 1, SOX2↓, 1, STAT3↓, 1, TOP2↓, 1, TumCG↓, 1, Wnt↓, 1,
Migration ⓘ
Ca+2↑, 2, E-cadherin↑, 2, FAK↓, 1, KLF2↓, 1, MMP2↓, 2, MMP9↓, 2, N-cadherin↓, 1, PKA↓, 1, Snail↓, 1, TIMP1↓, 1, TIMP2↓, 1, TumMeta↓, 1, uPA↓, 1, Vim↓, 2, ZO-1↑, 1, β-catenin/ZEB1↓, 2,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, Hif1a↓, 1, VEGF↓, 2, VEGFR2↓, 1,
Immune & Inflammatory Signaling ⓘ
IL6↓, 1, NF-kB↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1, CDK6↑, 2,
Drug Metabolism & Resistance ⓘ
Dose↝, 1, eff↑, 4, eff∅, 1,
Clinical Biomarkers ⓘ
AR↓, 1, BG↓, 1, IL6↓, 1,
Functional Outcomes ⓘ
TumVol↓, 1,
Total Targets: 97
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: ASK1, Apoptosis Signal-regulating Kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:918 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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