Cav1 Cancer Research Results

Cav1, Caveolin-1: Click to Expand ⟱
Source:
Type: protein
Caveolin-1 (Cav-1) is a protein that plays a crucial role in the structure and function of caveolae, which are small, flask-shaped invaginations of the plasma membrane found in many cell types. Cav-1 has been implicated in various cellular processes, including cell signaling, cholesterol transport, and apoptosis.

In the context of cancer, Cav-1 has been found to have both tumor-suppressive and tumor-promoting roles, depending on the type of cancer and the stage of disease progression.
Scientific Papers found: Click to Expand⟱
943- BetA,    Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
Glycolysis↓,
lactateProd↓,
GlucoseCon↓,
ECAR↓,
cMyc↓,
LDHA↓,
p‑PDK1↓,
PDK1↓,
Cav1↑, Cav-1) as one of key targets of BA in suppressing aerobic glycolysis, as BA administration resulted in Cav-1 upregulation
*Glycolysis↑, BA could lead to increased glycolysis in mouse embryonic fibroblasts by activating LKB1/AMPK pathway, whereas we found that BA inhibited aerobic glycolysis in breast cancer cells by modulating Cav-1/NF-κB/c-Myc signaling
selectivity↑,
OCR↓, OCR parameters including the basal respiration, maximal respiration and spare respiratory capacity were also simultaneously inhibited
OXPHOS↓, implying that the activity of mitochondrial oxidative phosphorylation (OXPHOS) chain was also suppressed by BA

942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Cav1↑, may impair the glycolytic metabolism of breast cancer cells by activating Caveolin-1 (Cav-1)
Glycolysis↓, Ursolic Acid Impairs the Glycolytic Metabolism
cMyc↓, ursolic acid (1~30 μM) treatment significantly attenuated the protein expression levels of both the glycolysis-related proteins (c-Myc and LDH-A)
LDHA↓,
Nrf1↓, and the mitochondrial respiration-related proteins (Nrf1 and PGC-1α)
PGC-1α↓,
Sp1/3/4↑, Mechanistically, ursolic acid could activate SP1-mediated CAV1 transcription by promoting SP1 expression
TumCG↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Nrf1↓, 1,   OXPHOS↓, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis ⓘ

Cav1↑, 2,   cMyc↓, 2,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDHA↓, 2,   PDK1↓, 1,   p‑PDK1↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Cav1, Caveolin-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:922  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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