α-tubulin Cancer Research Results

α-tubulin, α-tubulin: Click to Expand ⟱
Source:
Type:
α-Tubulin is a protein that is a component of microtubules, which are dynamic structures that play a crucial role in various cellular processes, including cell division, cell migration, and intracellular transport.
High α-tubulin expression is associated with poor prognosis, increased tumor size, and metastasis. α-Tubulin expression is also correlated with resistance to chemotherapy and hormone therapy. Generally, high α-tubulin expression is associated with:
      Poor prognosis
      Increased tumor size
      Metastasis
      Resistance to chemotherapy and radiation therapy
      Poor response to treatment

Low α-tubulin expression is associated with:
      Better prognosis
      Smaller tumor size
      Less metastasis
      Better response to chemotherapy and radiation therapy
      Better response to treatment
Scientific Papers found: Click to Expand⟱
2698- BBR,    A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Analysis, BC, MDA-MB-231
HDAC↓, Akt↓, mTOR↓, ER Stress↑, TumAuto↑, AMPK↑, mTOR∅, HDAC∅, ac‑α-tubulin↑,
1207- CA,  PacT,    Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa
TumCG↑, TumCMig↓, Apoptosis↓, ac‑α-tubulin↑,
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP90↓, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC∅, 1,   HDAC6↓, 2,   mTOR↓, 1,   mTOR∅, 1,   TumCG↑, 1,  

Migration ⓘ

MMP9↓, 2,   TumCI↓, 2,   TumCMig↓, 3,   α-tubulin↑, 2,   ac‑α-tubulin↑, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: α-tubulin, α-tubulin
2 Honokiol
1 Berberine
1 Caffeic acid
1 Paclitaxel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:933  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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