PPP Cancer Research Results

PPP, pentose phosphate pathway: Click to Expand ⟱
Source:
Type:
The pentose phosphate pathway (PPP) is a metabolic pathway that generates NADPH and pentoses from glucose-6-phosphate. In cancer, the PPP is often upregulated to support the increased demand for NADPH, which is necessary for fatty acid synthesis, antioxidant defenses, and maintaining the balance of redox reactions.

High expression of PPP enzymes is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, and ovarian cancer.
Scientific Papers found: Click to Expand⟱
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, Metabolomic analyses showed that 3BP causes inhibition of glycolysis
RadioS↑, Overall, MCT1-mediated metabolic perturbation in combination with radiotherapy is shown to be a promising strategy for the treatment of glycolytic tumors such as TNBC, overcoming the selectivity challenges of targeting glycolysis with glucose analogs
eff↑, 3BP is selectively toxic to cells expressing MCT1
GAPDH↓, 3BP inhibits GAPDH but not hexokinase
PPP↑, Pentose phosphate pathway is upregulated in response to 3BP
GSH↓, Glutathione and NADH are depleted at early time points
ECAR↓, prolonged incubation with 20 μM 3BP for 24 h resulted in a statistically significant selective decrease in ECAR

5156- PTL,    Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells
- in-vitro, AML, NA
NADPH↑, parthenolide leads to induction of compensatory mechanisms that include up-regulated NADPH production via the pentose phosphate pathway
PPP↑, Metabolomic analyses reveal increased PPP activity for NADPH production in PTL-treated AML cells. compensatory mechanisms
NRF2↑, activation of the Nrf2-mediated oxidative stress response pathway. compensatory mechanisms
ROS↑,
CSCs↓, parthenolide, 2-deoxyglucose, temsirolimus (termed PDT) regimen is a potent means of targeting AML stem cells but has little to no effect on normal stem cells
selectivity↑,
other↝, combined with 2-deoxyglucose (D) and temsirolimus (T), drugs chosen for their ability to inhibit the PPP and the Nrf-2 mediated anti-oxidant response, respectively


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   NRF2↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   GAPDH↓, 1,   Glycolysis↓, 1,   NADPH↑, 1,   PPP↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   RadioS↑, 1,   selectivity↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PPP, pentose phosphate pathway
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:948  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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