PGC1A Cancer Research Results

PGC1A, PPARγ Coactivator 1-alpha: Click to Expand ⟱
Source:
Type:
PPARγ Coactivator 1-alpha (PGC1A) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, including glucose and lipid metabolism. In cancer, PGC1A has been implicated in the regulation of tumor cell metabolism, proliferation, and survival.

PGC1A is typically overexpressed and associated with poor prognosis and reduced overall survival in breast, lung, and colon cancers.
-PGC1A expression is also associated with increased risk of metastasis and recurrence in various types of cancer.
Scientific Papers found: Click to Expand⟱
1006- CUR,    The effect of Curcuma longa extract and its active component (curcumin) on gene expression profiles of lipid metabolism pathway in liver cancer cell line (HepG2)
- in-vitro, Liver, HepG2
TumCP↓,
PGC1A↑,
CPT1A↑,
ACOX1↑,
SCD1↓,
SREBF2↓,
DGAT1↓,

3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, ↓Lipid peroxidation ↑SOD, CAT, GPx, GR, and GST, ↑GSH
*SOD↑,
*Catalase↑,
GPx↑,
*GR↑,
*GSTs↑,
*GSH↑,
*SIRT1↑, EGCG upregulated the levels of NAD+ -dependent protein deacetylase sirtuin-1 (SIRT1), peroxi- some proliferator-activated receptor  co-activator-1 (PGC-1), glutathione peroxidase (GPx), and SOD in MPP + -treated PC12 cells.
*PGC1A↑,
*other↑, EGCG (2 mg/kg day-1 administered through oral gavage for 30 days) upregulated the activities of brain mitochondrial antioxidant enzymes (SOD, CAT, and GPx) in aged, but not in young rats.

3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, RA reduced X-ray-induced the expression of inflammatory related factors, and the level of reactive oxygen species.
*ROS↓,
*p‑NF-kB↓, RA down-regulated the phosphorylation of nuclear factor kappa-B (NF-κB).
*Rho↓, RA attenuated RhoA/Rock signaling through upregulating miR-19b-3p, leading to the inhibition of fibrosis
*ROCK1↓,
*radioP↑, RA attenuated radiation- induced damage by its capacity to relieve inflammation and regulate inflammatory factors.
*MCP1↓, RA treatment reduced RNA levels of NF-kB target gene, including MCP-1, RANTES, and ICAM-1
*RANTES↓,
*ICAM-1↓,
*PGC1A↑, Western blot analysis showed that RA promoted the expression of PGC-1a and reduced the expression of NOX-4, this evidence further suggested that RA inhibits the generation of ROS
*NOX4↓,
*Dose↝, RA exerted strongly protective effects in the X-ray-induced inflammation at doses of 60 mg/kg, and treat- ment with a higher dose (120 mg/kg) do not enhance its anti- inflammatory effect.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACOX1↑, 1,   CPT1A↑, 1,   DGAT1↓, 1,   PGC1A↑, 1,   SCD1↓, 1,   SREBF2↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   NOX4↓, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

PGC1A↑, 2,   SIRT1↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

Rho↓, 1,   ROCK1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   Inflam↓, 1,   MCP1↓, 1,   p‑NF-kB↓, 1,   RANTES↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 20

Scientific Paper Hit Count for: PGC1A, PPARγ Coactivator 1-alpha
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Rosmarinic acid
1 Radiotherapy/Radiation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:955  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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