IAP1 Cancer Research Results

IAP1, cIAP1, cellular Inhibitor of Apoptosis Protein 1: Click to Expand ⟱
Source:
Type:
IAP1 (cIAP1, encoded by the gene BIRC2) is a member of the Inhibitor of Apoptosis (IAP) protein family.
• IAP proteins generally function by binding and inhibiting components of the cell death machinery, thereby promoting cell survival.
• Beyond their role in directly suppressing apoptosis, IAP proteins (including IAP1) are involved in regulating other signaling pathways—such as NF-κB—that can influence inflammation, immune responses, and cellular proliferation.

Overexpression of IAP proteins, including IAP1, has been observed in various tumor types. – High IAP1 levels can help tumor cells evade apoptosis (programmed cell death), contributing to tumor growth and progression.
• IAP1 may also influence the tumor microenvironment by modulating pro-survival and inflammatory signals.
Scientific Papers found: Click to Expand⟱
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,  

Cell Death ⓘ

BID↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   IAP1↑, 1,   ICAD↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Protein Folding & ER Stress ⓘ

HSP27↑, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

Smad1↑, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

Cyt‑c↓, 1,   IAP1↓, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: IAP1, cIAP1, cellular Inhibitor of Apoptosis Protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:979  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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