ADAM17 Cancer Research Results

ADAM17, A Disintegrin and Metalloprotease 17: Click to Expand ⟱
Source:
Type:
ADAM17 (A Disintegrin and Metalloprotease 17), also known as TACE (Tumor Necrosis Factor-α Converting Enzyme), is a membrane-anchored protease.
– It is best known for cleaving and releasing the extracellular domains (ectodomains) of various cell surface proteins, a process called “ectodomain shedding.”

Numerous studies have documented increased ADAM17 expression in several cancers, such as breast, lung, colon, and pancreatic cancers.
– Upregulation often correlates with enhanced release of growth factors (e.g., EGF family ligands) and cytokines that may drive tumor growth and modify the tumor microenvironment.
– Higher levels of ADAM17 have been linked with more aggressive tumor characteristics, including increased invasiveness, metastasis, and resistance to certain therapies.
– In cancers such as breast and lung, elevated ADAM17 expression is often associated with poor clinical prognosis.
Scientific Papers found: Click to Expand⟱
7497- H2S,    Hydrogen sulfide improves spatial memory impairment and decreases production of Aβ in APP/PS1 transgenic mice
- in-vivo, AD, NA
*other↓, *memory↑, *BACE↓, *ADAM17↑,
7498- H2S,    Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse
- in-vivo, AD, NA
*BACE↑, *ADAM17↑, *PSEN1/PS1↓, *PI3K↑, *Akt↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 2,  

Protein Aggregation(tgid=19) ⓘ

BACE↓, 1,   BACE↑, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: ADAM17, A Disintegrin and Metalloprotease 17
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:994  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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