Polyphenols / DNMTs Cancer Research Results

Poly, Polyphenols: Click to Expand ⟱
Features:

Polyphenols are a large and structurally diverse family of plant-derived phenolic compounds characterized by multiple phenolic hydroxyl groups and encompassing major subclasses including flavonoids, phenolic acids, stilbenes, lignans, and tannins. They occur widely in fruits, vegetables, herbs, tea, coffee, cocoa, and medicinal plant extracts. Polyphenols exhibit broad biological activity involving redox regulation, inflammatory signaling, kinase pathways, apoptosis, cell-cycle control, angiogenesis, metabolism, and epigenetic regulation. In cancer models, many polyphenols inhibit proliferation, promote apoptosis or senescence, suppress invasion and angiogenesis, and can alter sensitivity to chemotherapy or radiotherapy. Effects are highly compound-, dose-, and context-dependent; antioxidant activity in normal tissues may coexist with pro-oxidant ROS induction in cancer cells. Oral bioavailability is frequently limited by poor absorption and extensive intestinal, hepatic, and microbial metabolism, making high-concentration in-vitro findings difficult to extrapolate directly to human systemic exposure.

Polyphenols — broad umbrella class of plant-derived phenolic compounds.

  • Flavonoids
    • Flavones
      • Apigenin
      • Luteolin
    • Flavonols
      • Quercetin
      • Kaempferol
      • Fisetin
    • Flavan-3-ols
      • Catechin
      • Epicatechin
      • EGCG
    • Flavanones
      • Hesperetin
      • Naringenin
    • Isoflavones
      • Genistein
      • Daidzein
      • Formononetin
    • Anthocyanins
      • Cyanidin
      • Delphinidin
      • Pelargonidin
    • Chalcones
      • Isoliquiritigenin
      • Licochalcone A
      • Xanthohumol
      • Isobavachalcone
  • Phenolic acids
    • Hydroxybenzoic acids
      • Gallic acid
      • Protocatechuic acid
      • Ellagic acid
    • Hydroxycinnamic acids
      • Caffeic acid
      • Ferulic acid
      • p-Coumaric acid
      • Chlorogenic acid
      • Cynarin
  • Stilbenes
    • Resveratrol
    • Pterostilbene
  • Lignans
    • Secoisolariciresinol
    • Matairesinol
    • Enterolactone
    • Enterodiol
  • Tannins
    • Hydrolyzable tannins
      • Gallotannins
      • Ellagitannins
    • Condensed tannins
      • Proanthocyanidins
DNMTs, DNA methyltransferase: Click to Expand ⟱
Source:
Type:
DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses.

High expression levels of DNMTs, particularly DNMT1 and DNMT3A, are often associated with poor prognosis in several cancers. This is due to their role in promoting tumor growth, metastasis, and resistance to therapies.
Scientific Papers found: Click to Expand⟱
7430- Poly,    Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
- Review, Var, NA
*antiOx↑, ROS↑, CSCs↓, NF-kB↓, HDAC⇅, HATs⇅, DNMTs⇅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMTs⇅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   HDAC⇅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: DNMTs, DNA methyltransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:450  Target#:469  State#:%  Dir#:3
  wNotes=0  sortOrder:rid,rpid

 

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