CYP3A4 Cancer Research Results

CYP3A4, CYP3A4: Click to Expand ⟱

Source:

Type:

CYP3A4 is the most abundant cytochrome P450 enzyme in the liver and is also expressed in extrahepatic tissues.
– It metabolizes a wide range of drugs and endogenous substrates, including hormones.

– In some studies, higher CYP3A4 expression has been correlated with poorer response to treatment and potentially worse survival.

Scientific Papers found: Click to Expand⟱

6603-

Ech,

doxoR,

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel

Trial,

Var,

Ten evaluable cancer patients received docetaxel (135 mg, 60 min IV infusion) before intake of a commercially available E. purpurea extract (20 oral drops three times daily) and 3 weeks later after a 14 day supplementation period with E. purpurea.

other∅, The multiple treatment of E. purpurea did not significantly alter the pharmacokinetics of docetaxel in this study.
other↝, The applied E. purpurea product at the recommended dose may be combined safely with docetaxel in cancer patients.
Imm↑, herbal immunostimulant Echinacea purpurea (E. purpurea) is widely used among cancer patients.
CYP3A4⇅, E. purpurea has been shown to induce cytochrome P450 3A4 (CYP3A4) in vitro and in clinical studies. Echinacea extracts have the potential to inhibit CYP3A4 in vitro [9, 10]. There are indications that Echinacea is also capable of inducing CYP3A4.
other↑, In a survey including 318 cancer patients, Echinacea was the most popular herbal medicine, used by 21% of all users of complementary and alternative medicines

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4⇅, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1, other↝, 1, other∅, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CYP3A4, CYP3A4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells