Imm Cancer Research Results
Imm, immunostimulatory: Click to Expand ⟱
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Enhance the immune response in patients.
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Scientific Papers found: Click to Expand⟱
*antiOx↑, anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function.
AntiCan↑,
*cardioP↑, Research on flavonoids received an added impulse with the discovery of the low cardiovascular mortality rate and also prevention of CHD.
*XO↓, They are also known to be potent inhibitors for several enzymes, such as xanthine oxidase (XO), cyclo-oxygenase (COX), lipoxygenase and phosphoinositide 3-kinase
*COX2/PTGS2↓,
*5LO↓,
*PI3K↓,
*AChE↓, A number of flavonoids have been reported for their anti-cholinesterase activity.
*Imm⇅, These effects indicate the immune-regulatory roles of flavonoids.
*BP↓, regular quercitin intake on blood pressure in overweight and obese patients with pre-hypertension and stage I hypertension was studied in seventy patients.
TumCCA↑, t pelingo juice induced cell accumulation in the G2/M phase of the cell cycle
*Aβ↓, certain flavonoids such as genistein, quercetin, taxifolin, kaemferol, luteolin, apigenin, daidzein, aminogeneistein, and α- and β-napthofalvone can affect Aβ production.
*BACE/β-secretase↓, direct inhibition of β active site cleavage enzyme-1 (BACE-1) activity
*NF-kB↓, inhibition of NF-κB activation by flavonoids
*ROS↓, flavones and catechins seem to be the most powerful flavonoids for protecting the body against reactive oxygen species.
*neuroP↑, like prevention of the neurodegeneration associated with AD and Parkinson's disease
*AntiAg↑, figure 3
*AntiThr↑,
*toxicity↓, Fucoidan is a versatile, nontoxic marine-origin heteropolysaccharide that has received much attention due to its beneficial biological properties and safety.
*AntiViral↑, ucoidan has been demonstrated to exhibit a variety of conventional bioactivities, such as antiviral, antioxidant, and immune-modulatory characteristics, and anticancer activity against a wide range of malignancies has also recently been discovered.
*antiOx↑,
*Imm⇅,
AntiCan↑,
TumCCA↑, Fucoidan inhibits tumorigenesis by prompting cell cycle arrest and apoptosis, blocking metastasis and angiogenesis, and modulating physiological signaling molecules.
Apoptosis↑,
TumMeta↓,
angioG↓,
antiNeop↑, Fucoidans’ capacity to bind to Toll-like receptors and intervene with the action of vascular endothelial growth factors (VEGF) and matrix metalloproteinases (MMPs) could explain their anti-neoplastic properties
VEGF↓,
MMPs↓,
BioAv↑, Low molecular weight fractions (LMWF), in particular, are thought to be more biocompatible [47]
BioAv↑, in rats, following topical administration of fucoidan (MW 750 kDa) from Fucus vesiculosus demonstrated fine skin-penetrating characteristics.
ROS⇅, Induction/inhibition of reactive oxygen species (ROS), mitochondrial instability, and caspase and poly (ADP-ribose) polymerase (PARP) cleavage are all aspects of it
cl‑PARP↑, fucoidan treatment causes PARP cleavage and caspase-3/7 activation in MCF-7 cells, which are hallmarks of apoptosis [
Casp3↑,
Casp7↑,
ROS↑, human hepatoma SMMC-7721 cells, fucoidan therapy caused noteworthy growth inhibition and ROS-mediated apoptosi
GSH↓, lower glutathione consumption (GSH), mitochondrial swelling, and depolarization of the mitochondrial membrane potential
MMP↓,
PI3K↓, Fucoidan inhibits PI3K, suppressing ERK and activates MAPK, limiting cancer cell proliferation and decreasing Bcl-2 to Bax ratio, inducing caspase-dependent apoptosis in BEL-7402 and LM3 cell lines
ERK↓,
MAPK↑,
TumCP↓,
Bax:Bcl2↑,
TJ↑, Meanwhile, dietary fucoidan progressively restores intestinal villi by upregulating the expression of tight junction proteins such as ZO-1, Occludin, Claudin-1, and Claudin-8 via p38 MAPK and ERK1/2 activation.
ZO-1↑,
OCLN↑,
CLDN1↑,
IBI↑, fucoidan supplementation improves intestinal barrier function by enhancing intestinal microbiota diversity
GutMicro↑,
NK cell↑, ↑NK cell-mediated anticancer immunity
STAT3↓, Inhibits STAT3 Signaling
eff↑, Astragalus polysaccharide as a topical mucosal adjuvant to boost the anticancer efficacy of immune checkpoint inhibitors
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
GSH↓, 1, ROS↑, 1, ROS⇅, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 1, Bax:Bcl2↑, 1, Casp3↑, 1, Casp7↑, 1, MAPK↑, 1,
DNA Damage & Repair(tgid=10) ⓘ
cl‑PARP↑, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
TumCCA↑, 2,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
ERK↓, 1, PI3K↓, 1, STAT3↓, 1,
Migration(tgid=13) ⓘ
CLDN1↑, 1, MMPs↓, 1, TJ↑, 1, TumCP↓, 1, TumMeta↓, 1, ZO-1↑, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1, VEGF↓, 1,
Barriers & Transport(tgid=15) ⓘ
IBI↑, 1, OCLN↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
NK cell↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↑, 2, eff↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
GutMicro↑, 1,
Functional Outcomes(tgid=23) ⓘ
AntiCan↑, 2, antiNeop↑, 1,
Total Targets: 30
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 2, ROS↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
AntiThr↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
PI3K↓, 1,
Migration(tgid=13) ⓘ
5LO↓, 1, AntiAg↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, Imm⇅, 2, NF-kB↓, 1,
Synaptic & Neurotransmission(tgid=18) ⓘ
AChE↓, 1,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 1, BACE/β-secretase↓, 1, XO↓, 1,
Clinical Biomarkers(tgid=22) ⓘ
BP↓, 1,
Functional Outcomes(tgid=23) ⓘ
cardioP↑, 1, neuroP↑, 1, toxicity↓, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiViral↑, 1,
Total Targets: 18
Scientific Paper Hit Count for: Imm, immunostimulatory
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1332 State#:% Dir#:3
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