chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
5959- CEL,    Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-κB as a possible target
- in-vitro, Cerv, HeLa
Apoptosis↑, Celecoxib induced apoptosis independent of COX-2 activity.
Casp8↑, This event accompanied the activation of caspase-8 and -9 with Bid cleavage and the loss of mitochondrial membrane potential.
Casp9↑,
cl‑BID↑,
MMP↓,
NF-kB↑, Celecoxib-induced apoptosis is associated with NF-κB activation.
Dose⇅, The chemopreventive effect of celecoxib was also achieved only at relatively high doses (400–800 mg daily) in a human clinical trial, but not at a therapeutic daily dose of 200 mg
chemoPv⇅,
COX2↓, less than 10 μM of celecoxib is needed to inhibit the COX activity, while the concentrations required to inhibit tumor cell growth range from 30 μM to 100 μM


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   cl‑BID↑, 1,   Casp8↑, 1,   Casp9↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose⇅, 1,  

Functional Outcomes ⓘ

chemoPv⇅, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:3
  wNotes=on  sortOrder:rid,rpid

 

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