TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
Scientific Papers found: Click to Expand⟱
5598- NaHCO3,    Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- in-vivo, BC, MDA-MB-231
e-pH↑, Here, we show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. significantly increase the extracellular pH, but not the intracellular pH,
TumMeta↓,
TumCG⇅, Despite a lack of an effect on primary tumor growth, bicarbonate therapy led to significant reductions in the number and size of metastases to lung, intestine, and diaphragm.
Dose↑, The daily intake of bicarbonate was thus calculated to be 36 ± 1.7 mmol/kg/d (9.4 g/m2/d). An equivalent dose in a 70-kg human would be 12.5 g/d (20).

4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Spermidine has dual effects on cancers by targeting oncogenes, immunity, autophagy or apoptosis.
Apoptosis↑,
OS↑, Dietary spermidine intake has association with prolonged survival of cancer patients at the early stage.
CRM↑, increased uptake of spermidine as a caloric restriction mimic can reduce overall mortality associated with cancers.
TumCG⇅, Increased intake of polyamine seems to suppress tumorigenesis, but appears to accelerate the growth of established tumors.
cardioP↑, spermidine can protect from pathological events including two major death causes: cardiovascular disease (CVD) and cancer [15]
cognitive↑, and other aging-related diseases such as cognitive impairment during Alzheimer’s disease (AD) and Parkinson’s disease (PD)
*Dose⇅, spermidine at too high level could be detrimental to patients suffering from cancer, aging, innate immunity and cognitive impairment during AD and PD


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

CRM↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG⇅, 2,  

Migration ⓘ

TumMeta↓, 1,  

Cellular Microenvironment ⓘ

e-pH↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   OS↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

Dose⇅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: TumCG, Tumor cell growth
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:323  State#:%  Dir#:3
  wNotes=on  sortOrder:rid,rpid

 

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