other Cancer Research Results

other, other: Click to Expand ⟱
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Scientific Papers found: Click to Expand⟱
4051- ,    Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women
- Study, AD, NA
*cognitive↑, The odds of IADL impairment increased significantly with decreasing intake of vitamins B2, B6, and B12
*neuroP↑, possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats, and B-group vitamins, and support dietary intervention to prevent cognitive decline.
*other↝, Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy dessert and ice-cream.
*other⇅, IADL impairment was associated with lower intake of vegetables

4008- K+,    Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update
- Review, AD, NA
*other⇅, t is therefore not surprising that an improper functioning of K+ channels in neurons has been associated with pathophysiology of a wide range of neurological disorders, especially Alzheimer's disease (AD).

2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
ROS?, Piperlongumine, a natural alkaloid isolated from the long pepper, selectively increases reactive oxygen species production and apoptotic cell death in cancer cells but not in normal cells.
*ROS∅,
other⇅, opposing effect of piperlongumine appears to be mediated by heme oxygenase-1 (HO-1)
HO-1↑, Piperlongumine upregulated HO-1 expression through the activation of nuclear factor-erythroid-2-related factor-2 (Nrf2) signaling in both MCF-7 and MCF-10A cells.
*HO-1↑,
NRF2↑, piperlongumine-induced Nrf2 activation, HO-1 expression and cancer cell apoptosis are not dependent on the generation of reactive oxygen species.
Keap1↓, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1)
cl‑PARP↑, Following piperlongumine treatment, cleaved PARP levels increased in time- (Fig. 1D) and dose-dependent
selectivity↑, These data clearly show that piperlongumine has a cancer cell-selective killing effect
GSH↓, piperlongumine can selectively decrease the level of reduced GSH and increase the level of oxidized GSSG, leading to ROS accumulation and subsequent apoptosis in cancer cells
GSSG↑, we observed piperlongumine-mediated depletion of GSH, a reduction in the GSH/GSSG ratio and accumulation of intracellular ROS in MCF-7 cells but not in MCF-10A cells


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSSG↑, 1,   HO-1↑, 1,   Keap1↓, 1,   NRF2↑, 1,   ROS?, 1,  

Transcription & Epigenetics ⓘ

other⇅, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   ROS∅, 1,  

Transcription & Epigenetics ⓘ

other⇅, 2,   other↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: other, other
1 Potassium
1 Piperlongumine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:767  State#:%  Dir#:3
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