RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
Source:
Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
6862- FBZ,    Research: The Urgent Need for Clinical Studies to Evaluate the Anti-Tumor Efficacy of Fenbendazole
- Review, Var, NA
mitA↑, FBZ destabilizes microtubules, critical for cell division, leading to mitotic arrest and apoptosis.
Apoptosis↑,
GLUT4↓, FBZ inhibits glucose uptake by downregulating GLUT transporters and hexokinase II, starving cancer cells reliant on aerobic glycolysis (Warburg effect).
HK2↓,
Warburg↓,
TumCCA↑, FBZ induces G2/M phase arrest and promotes apoptosis via p53 activation and caspase activation.
P53↑,
Casp↑,
TumCP↓, confirmed dose-dependent proliferation inhibition and apoptosis.
ROS↑, FBZ induces reactive oxygen species (ROS) accumulation, enhancing ferroptosis and apoptosis, particularly in 5-fluorouracil-resistant colorectal cancer cells.
Ferroptosis↑,
TumVol↓, A549 lung cancer xenografts in nude mice, reported significant tumor shrinkage with oral FBZ administration (1 mg/mouse every 2 days for 12 days).
Dose↝, The case of Joe Tippens, who reported complete remission from stage IV small-cell lung cancer after taking FBZ (222 mg daily) alongside vitamin E, CBD oil, and curcumin, has fueled public interest.
BioAv↓, FBZ’s poor water solubility and low systemic bioavailability limit its ability to reach therapeutic levels in tumors when administered orally.
RadioS↝, Given preclinical evidence of synergy with radiation or docetaxel, trials should explore FBZ’s role as an adjunct to conventional treatments, potentially enhancing efficacy in resistant cancers.
ChemoSen↑,

5079- SSE,  Rad,    The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
chemoP↑, Sodium selenite is often given to moderate the side effects of cancer therapy to enhance the cellular defence of non-cancerous cells.
eff↝, the effect of sodium selenite on radiation response is strongly dependent on the respective experimental in vitro conditions and ranges from lead to an initially suspected but ultimately no real radioprotection
ROS↑, The selenite-mediated ROS generation
MMP↓, Selenite leads to a decrease in the mitochondrial membrane potential and to the release of cytochrome c into the cytosol, which ultimately activates the apoptotic pathway
Cyt‑c↑,
TumCG↓, In our study, the growth of A549 tumour cells was more sensitive to sodium selenite than the normal BEAS-2B cells.
RadioS↝, However, in our study, no general difference in radiosensitivity between the tumour (A549) and normal (BEAS-2B) cells under the influence of sodium selenite could be observed.
other↝, results support the previous results on the potential for the use of sodium selenite in radiation therapy, but also illustrate the urgent need and importance of further elucidating the mechanisms of action of sodium selenite


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

HK2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

mitA↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↝, 1,   RadioS↝, 2,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   TumVol↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RadioS, RadioSensitizer
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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